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4-ANPP, also known as 4-anilino-N-phenethylpiperidine (4-ANPP), 4-aminophenyl-1-phenethylpiperidine, or despropionyl fentanyl,^[3] is a direct precursor to fentanyl and acetylfentanyl. It is commonly found as a contaminant in samples of drugs containing fentanyl, which may include samples represented by the supplier as heroin or other opioids.^[4] It is not psychoactive and is present only as a result of improper chemical purification. Order 4-Anilino-N-phenethylpiperidine (4-ANPP) Precursor

4-ANPP is useful in the synthesis of pharmaceuticals, primarily fentanyl and related analogs. Paul Janssen (founder of Janssen Pharmaceutica) first synthesized fentanyl in 1960 using a similar method, with Benzylfentanyl as an intermediate.^[5] The following synthesis, developed by an individual under the pseudonym of Siegfried, involves the reductive amination of N–phenethyl-4-piperidinone (NPP) with aniline to make to 4-ANPP. This product is reacted with propionyl chloride or acetyl chloride to form either fentanyl or acetylfentanyl. Order 4-Anilino-N-phenethylpiperidine (4-ANPP) Precursor 

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Buy 4-Anilino-N-phenethylpiperidine (4-ANPP). 4-ANPP-¹³C₆ (CRM) is a certified reference material intended for use as an internal standard for the quantification of 4-ANPP by GC- or LC-MS. 4-ANPP is categorized as a piperidinamine. It is an intermediate in the synthesis of fentanyl from N-phenethyl-4-piperidone .¹ As such, 4-ANPP has been used as a precursor for the manufacture of fentanyl and related opioids. 4-ANPP is also an impurity found in fentanyl preparations. It is a known metabolite of acetyl fentanyl , butyryl fentanyl , furanyl fentanyl , acrylfentanyl , and fentanyl.^2,3,4,5 4-ANPP-¹³C₆ is regulated as a Schedule II compound in the United States. This product is intended for research and forensic applications. Buy 4-Anilino-N-phenethylpiperidine (4-ANPP)

4-ANPP, also known as 4-anilino-N-phenethylpiperidine (4-ANPP), 4-aminophenyl-1-phenethylpiperidine, or despropionyl fentanyl,^[3] is a direct precursor to fentanyl and acetylfentanyl. It is commonly found as a contaminant in samples of drugs containing fentanyl, which may include samples represented by the supplier as heroin or other opioids.^[4] It is not psychoactive and is present only as a result of improper chemical purification. Buy 4-Anilino-N-phenethylpiperidine (4-ANPP)

4-ANPP is useful in the synthesis of pharmaceuticals, primarily fentanyl and related analogs. Paul Janssen (founder of Janssen Pharmaceutica) first synthesized fentanyl in 1960 using a similar method, with Benzylfentanyl as an intermediate.^[5] The following synthesis, developed by an individual under the pseudonym of Siegfried, involves the reductive amination of N–phenethyl-4-piperidinone (NPP) with aniline to make to 4-ANPP. This product is reacted with propionyl chloride or acetyl chloride to form either fentanyl or acetylfentanyl. Order 4-Anilino-N-phenethylpiperidine (4-ANPP) Precursor

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1.Pease, J.P., LePine, A.J., and Smith, C.M.Methods for preparing fentanyl and fentanyl intermediatesPatent Application PublicationUS 2013/0281702 A1(2013) 2.Watanabe, S., Vikingsson, S., Roman, M., et al.In vitro and in vivo metabolite identification studies for the new synthetic opioids acetylfentanyl, acrylfentanyl, furanylfentanyl, and 4-fluoro-isobutyrylfentanylAAPS J.19(4)1102-1122(2017) 3.Labroo, R.B., Paine, M.F., Thummel, K.E., et al.Fentanyl metabolism by human hepatic and intestinal cytochrome P450 3A4: Implications for interindividual variability in disposition, efficacy, and drug interactionsDrug Metab. Dispos.25(9)1072-1079(1997) 4.Melent’ev, A.B., Kataev, S.S., and Dvorskaya, O.N.Identification and analytical properties of acetyl fentanyl metabolitesJ. Anal. Chem.70(2)216-224(2015) 5.Steuer, A.E., Williner, E., Staeheli, S.N., et al.Studies on the metabolism of the fentanyl-derived designer drug butyrfentanyl in human in vitro liver preparations and authentic human samples using liquid chromatography-high resolution mass spectrometry (LC-HRMS)Drug Test Anal.9(7)1085-1092(2017)

4-ANPP (Item No. 18810) is an analytical reference material categorized as an opioid metabolite and a precursor in the synthesis of fentanyl (Item Nos. ISO60197 | 22659 | 14719) and other opioids. 1, 2, 3, 4, 5 4-ANPP is a metabolite of acetyl fentanyl (Item Nos. ISO60128 | ISO00128), butyryl fentanyl (Item Nos. 19734 | 14728), furanyl fentanyl (Item Nos. 19633 | 18705), acrylfentanyl (Item Nos. 23060 | 19312), and fentanyl. 1, 2, 3, 4 It has also been found as an impurity in illicit fentanyl preparations. 6 4-ANPP is regulated as a Schedule II compound in the United States.

4-ANPP (N-phenyl-1- (2-phenylethyl) -4-piperidinamine), a new opioid drug, classified as piperidinamine, synthesized as an intermediate between fentanyl from N-phenethyl-4-piperidone. 4-ANPP is a metabolite of acetylfentanil, butyrylfentanyl, furanylfentanil, acrylfentanyl and fentanyl. 4-ANPP is produced on modern chemical equipment, by professionals who know their business, which makes it clean and of high quality.

4-ANPP and other chemicals sold on this website are designed and must be used strictly for research and forensic medical examination.

Adverse properties of have not been studied.

Storage conditions of this chemical: in a cool and dry place. The stability of this chemical compound can last up to 2 years, under the right storage conditions.