Buy Mescaline Cas 54-04-6

Buy Mescaline Cas 54-04-6

Mescaline, also known as mescalin or mezcalin,^[13] and in chemical terms 3,4,5-trimethoxyphenethylamine, is a naturally occurring psychedelic protoalkaloid of the substituted phenethylamine class, found in cacti like peyote (Lophophora williamsii) and San Pedro (certain species of the genus Echinopsis) and known for its serotonergic hallucinogenic effects.^[6][1][8]

Mescaline is typically taken orally and used recreationally, spiritually, and medically, with psychedelic effects occurring at doses from 100 to 1,000 mg, including microdosing below 75 mg, and it can be consumed in pure crystalline form or via the crude extract of mescaline-containing cacti. Mescaline induces a psychedelic experience characterized by vivid visual patterns, altered perception of time and self, synesthesia, and spiritual effects, with an onset of 0.5 to 0.9 hours and a duration that increases with dose, ranging from about 6 to 14 hours. Ketanserin blocks mescaline’s psychoactive effects, and while it’s unclear if mescaline is metabolized by monoamine oxidase enzymes, preliminary evidence suggests harmala alkaloids may potentiate effects.

Mescaline primarily acts as a partial agonist at serotonin 5-HT_2A receptors, with varying affinity and efficacy across multiple serotonin, adrenergic, dopamine, histamine, muscarinic, and trace amine receptors, but shows low affinity for most non-serotonergic targets. It is a relatively hydrophilic psychedelic compound structurally related to catecholamines but acting instead on the serotonergic system, first synthesized in 1919, with numerous synthetic methods and potent analogues developed since. Mescaline occurs naturally in various cacti species, with concentrations varying widely, and is biosynthesized in plants from phenylalanine via catecholamine pathways likely linked to stress responses.

Mescaline-containing cacti use dates back over 6,000 years.^[6] Peyote was studied scientifically in the 19th and 20th centuries, culminating in the isolation of mescaline as its primary psychoactive compound, legal recognition of its religious use, and ongoing exploration of its therapeutic potential. Mescaline and the cacti that produce it are largely illegal worldwide, though exceptions exist for religious, scientific, or ornamental use, and the compound has influenced many notable cultural figures through its psychoactive effects. Very few studies concerning mescaline’s activity and potential therapeutic effects in people have been conducted since the early 1970s.

Mescaline is used recreationally, spiritually (as an entheogen), and medically.^[6][1] It is typically taken orally.^[2] The drug is used as a psychedelic at doses of 100 to 1,000 mg orally.^[8][14][15] Low doses are 100 to 200 mg, an intermediate or “good effect” dose is 500 mg, and a high (ego-dissolution) dose is 1,000 mg.^[8][14] Microdosing involves the use of subthreshold mescaline doses of less than 75 mg.^[8][14] In addition to pure form, mescaline is used in the form of mescaline-containing cacti such as peyote and San Pedro.^[6]

The onset of the effects of mescaline given orally is 0.5 to 0.9 hours on average with a range of 0.1 to 2.7 hours.^[8][9][1][2] Its effects peak after 1.9 to 4.0 hours with a range of 0.5 to 8.0 hours.^{[8][16][10][9]} The duration of mescaline appears to be dose-dependent, varying from 6.4 hours on average (range 3.0–10 hours) at a dose of 100 mg, 9.7 to 11 hours on average (range 5.6–22 hours) at moderate doses of 300 to 500 mg, and 14 hours on average (range 7.2–22 hours) at a dose of 800 mg.^[8][9]

Mescaline induces a psychedelic state comparable to those produced by LSD and psilocybin, but with unique characteristics.^[17] Subjective effects may include altered thinking processes, an altered sense of time and self-awareness, and closed– and open-eye visual phenomena.^[18] In his book PiHKAL (Phenethylamines I Have Known and Loved), Alexander Shulgin comprehensively described the effects of mescaline based on a collection of experience reports.^[19] Its effects included brightened colors, increased visual contrast, open-eye visuals like colors and patterns, pareidolia, increased significance of objects, enhanced music appreciation, feeling intoxicated, self-analysis, insights, increased body awareness, feelings of joy, happiness, and peacefulness, feeling hyper and energized, feelings of empathy, things feeling ridiculous, humor and laughter, religious feelings, restlessness, social discomfort and avoidance, and nausea, among others.^[19] Mescaline was one of Shulgin’s “magical half-dozen” psychedelic compounds in PiHKAL.^[19]

Prominence of color with mescaline is distinctive, appearing brilliant and intense.^[6] Recurring visual patterns observed during the mescaline experience include stripes, checkerboards, angular spikes, multicolor dots, and very simple fractals that turn very complex.^[20] The English writer Aldous Huxley described these self-transforming amorphous shapes as like animated stained glass illuminated from light coming through the eyelids in his autobiographical book The Doors of Perception (1954).^[21] Like LSD, mescaline induces distortions of form and kaleidoscopic experiences but they manifest more clearly with eyes closed and under low lighting conditions.^[20] Heinrich Klüver coined the term “cobweb figure” in the 1920s to describe one of the four form constant geometric visual hallucinations experienced in the early stage of a mescaline trip: “Colored threads running together in a revolving center, the whole similar to a cobweb”.^[22] The other three are the chessboard design, tunnel, and spiral.^[22] Klüver wrote that “many ‘atypical’ visions are upon close inspection nothing but variations of these form-constants.”^[22] An unusual but unique characteristic of mescaline use is the “geometrization” of three-dimensional objects.^[20][23] The object can appear flattened and distorted, similar to the presentation of a Cubist painting.^[20][23]

According to a study in the Netherlands, ceremonial San Pedro use seems to be characterized by relatively strong spiritual experiences, and low incidence of challenging experiences.^[24]

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