Buy Ergine (LSA or LAA) Cas 478-94-4

Buy Ergine (LSA or LAA) Cas 478-94-4

 

Ergine, also known as lysergic acid amide (LSA or LAA) as well as LA-111, is a psychoactive compound of the ergoline and lysergamide families related to lysergic acid diethylamide (LSD).^{[10][13][9][14]} Ergine is an ergoline alkaloid found in fungi such as Claviceps paspali (ergot) and Periglandula species such as Periglandula clandestina,^[13][15] which are permanently connected with many morning glory vines.^[13] Ergine induces relatively mild psychedelic effects as well as pronounced sedative effects.^{[10][16][17][18][19][20][21]}

The most common sources of ergine for use as a drug are the seeds of morning glory species including Ipomoea tricolor (tlitliltzin), Ipomoea corymbosa (ololiuhqui), and Argyreia nervosa (Hawaiian baby woodrose).^{[13][22][16][23]} Morning glory seeds have a history of entheogenic use in Mesoamerica dating back at least hundreds of years.^[13][18][24] They have also since been used by many Westerners.^[25] In addition to ergine, morning glory seeds contain other ergolines such as lysergic acid hydroxyethylamide (LSH), lysergic acid propanolamide (ergonovine), and isoergine.^[17][18][13] Some of these compounds are pharmacologically active and are thought to contribute to the effects of the seeds as well.^{[17][18][13][26][27]} There has been debate about the role of ergine in causing the psychedelic effects of morning glory seeds.^{[16][28][29][20]}

Ergine was first described by Sidney Smith and Geoffrey Timmis after they isolated it from ergot in 1932.^[12] It was first synthesized subsequent to its isolation in the 1930s.^[17][30] Albert Hofmann, the discoverer of LSD’s psychedelic effects in 1943, evaluated the effects of ergine in humans in 1947 and described the results many years later.^{[16][17][27][31]} He and his colleagues also isolated ergine from morning glory seeds in 1960.^{[32][33][17][13]} Morning glory seeds started to become frequently used as a recreational drug that same year^[25] and have been widely used since.^{[13][32][34][35]} Recreational use of morning glory seeds may be increasing due to their inexpensiveness, widespread availability, and lack of legal restrictions.^[10][32] Ergine has been encountered as a novel designer drug in Europe.^[36] Ergine, though not morning glory seeds, has become a controlled substance in various places in the world.^[37][38]

Ergine is most commonly used as a drug in the form of morning glory seeds, including those of Ipomoea tricolor (tlitliltzin), Ipomoea corymbosa (ololiuhqui), and Argyreia nervosa (Hawaiian baby woodrose).^[13] They may be consumed whole and intact, crushed or ground up, or drunk as an extract following soaking of the seeds in water.^[39][9][10] A hallucinogenic dose (~0.5–1 mg) is 150 to 200 seeds (3–6 g) of Ipomoea tricolor (0.02% ergine by dry weight) or 5 to 10 seeds (0.5–1 g) of Argyreia nervosa (0.14% ergine by dry weight).^{[39][9][10][25][20]} The onset is 0.3 to 3 hours and the duration is 4 to 10 hours.^[39][9][10]

Ergine may be used as a drug in pure or purified form as well, either isolated or synthesized.^[16][19][40] Albert Hofmann and colleagues found that a 0.5 to 2 mg dose by intramuscular or subcutaneous injection produced relatively weak but significant hallucinogenic effects as well as marked sedation.^{[16][17][31][25][19][40][41]} Another study described the effects of pure ergine by injection but the doses were not clearly provided (although appeared to be around 0.1–1 mg).^{[25][32][42][43]} Based on the preceding studies, Alexander Shulgin describes pure ergine as having a dosage of 0.5 to 1 mg and being 10-fold less potent than LSD, but as being “not hallucinogenic”.^[28] Hofmann also stated that ergine was 10- to 40-fold less potent than LSD and that it had qualitatively different effects.^[31][41] Robert Oberlender has stated that ergine is about 30-fold less potent than LSD in humans.^[44] Heim and colleagues assessed ergine at higher doses of 3 to 6 mg orally and observed toxic-like effects, whereas isoergine at 2 to 5 mg orally produced notable hallucinogenic effects, including some euphoria, synaesthesia, and altered time perception.^[20][45][27]

Per Shulgin in his 1997 book TiHKAL (Tryptamines I Have Known and Loved) however, both ergine and isoergine are “probably correctly dismissed” as not contributing to the effects of morning glory seeds.^[16] The poorly-stable lysergic acid hydroxyethylamides (LSHs) might alternatively be involved in the psychedelic effects of morning glory seeds per Shulgin.^[46]

Sleepy grass (Achnatherum robustum) and Claviceps paspali (ergot) have similar ergoline constituents as morning glory seeds and have also been used to produce psychoactive effects, albeit rarely.^[47][48]

Ergine has only been given a minuscule amount of attention. Albert Hofmann and his colleagues self-administered ergine.^[17] In addition, it was assessed in two clinical studies by other researchers.^[42][27] Synthetic ergine was used in all of these cases.^[42][17][27] Hofmann stated that ergine induces a “psychotomimetic” effect with “a marked narcotic component”: “Tired, dreamy, incapable of clear thoughts. Very sensitive to noises which give an unpleasant sensation.”^[17] There are parallels between Hofmann’s comments and the ones in the two trials:^[17]

Clinical studies of ergine’s effects

Hofmann (1963)[17]	Heim et al. (1968)[27]	Solms (1956)[42][43]
	“dysphoria”	“irritative depressive moods”
“incapable of clear thoughts”	“impairment of concentration””clouding of consciousness”	“impaired concentration””clouding of consciousness” “With middle to strong doses in 1 subject work became increasingly difficult after 30 minutes”
“Desire to lie down and sleep. Genuine physical and mental tiredness, which is not experienced as an unpleasant sensation. Slept for 3 hours.”	“test subject SB […] had to go to bed after an antineoplastic injection and did not recover until the following day.””In the fourth and fifth study periods, however, they appeared to be sufferingly exhausted and even sleepy and dazed.” [isoergine]	“and an immediate desire to sleep, after which he slept for three hours during the day”.
“a feeling of mental emptiness and of the unreality and complete meaninglessness of the outside world”. [isoergine]	“In the test subject PS (5 mg), severe nausea with a drop in blood pressure suddenly occurred after 3½ hours, which was controlled with analeptics and antinausea after about 30 minutes. At the same time, the test subject experienced a feeling of total annihilation and fear of death, which subsided after vomiting about 60 minutes later, but only completely subsided during the course of the night.” [isoergine]”In the fourth and fifth study cross-sections, they complained of difficulty in thinking and a lack of ideas.” [isoergine]	“Indifference””a feeling of sinking into nothing”

Heim 1968 also noted “paraesthesia”, “synesthesia” and an “overestimation of the time that had passed” (isoergine), but also concluded, “our experiments with ᴅ-lysergic acid amide also confirm the results that Sᴏʟᴍꜱ had made with this substance, namely a predominantly sedative intoxication.” Hofmann emphasized this sedative effect:^{[excessive quote]}

“Furthermore there is not only a quantitative difference between the principles of Ipomoea [tricolor] and Turbina corymbosa and LSD; there is likewise a qualitative one, LSD being a very specific hallucinogen, whereas the psychic effects of lysergic acid amide and the total alkaloids of these two plants are characterized by a pronounced narcotic component (Hofmann, 1968).”^[49]

“A substance very closely related to LSD, the monoethylamide of lysergic acid (LAE-32), in which an ethyl group is replaced by a hydrogen atom on the diethylamide residue of LSD, proved to be some ten times less psychoactive than LSD. The hallucinogenic effect is also qualitatively different: it is characterized by a narcotic component. This narcotic effect is yet more pronounced in lysergic acid amide (LA-111), in which both ethyl groups of LSD are displaced by hydrogen atoms. These effects, which I established in comparative self-experiments with LA-111 and LAE-32, were corroborated by subsequent clinical investigations.”^[31]

“The experience had some strong narcotic effect, but at the same time there was a very strange sense of voidness. In this [void], everything loses its meaning. It is a very mystical experience.”^[14]

While its physiological effects vary from person to person, the following symptoms have been attributed to the consumption of ergine or ergine containing seeds: sedation, visual hallucinations, auditory hallucinations, euphoria, loss of motor control, nausea, vasoconstriction, delusions, anxiety, paranoia, and irregular heartbeats.^{[23][50][51][52]}

One study found that two of four human subjects experienced cardiovascular dysregulation and the study had to be halted, concluding that the ingestion of seeds containing ergine was less safe than commonly believed. Importantly this may have been a product of other substances within the seeds. The same study also observed that reactions were highly differing in type and intensity between different subjects.^[52]