Buy (MDA) 3-4-Methylenedioxyamphetamine Cas-4764-17-4
Buy (MDA) 3-4-Methylenedioxyamphetamine Cas-4764-17-4
3,4-Methylenedioxyamphetamine (MDA) is an entactogen, stimulant, and psychedelic drug of the amphetamine and MDxx families that is encountered mainly as a recreational drug.[4][5][6] It is usually taken orally.[4][6]
In terms of its pharmacology, MDA is a serotonin–norepinephrine–dopamine releasing agent (SNDRA) and a serotonin 5-HT2 receptor agonist, including of the serotonin 5-HT2A receptor.[4] It has a duration of 5 to 8 hours or around 6 hours typically.[4][3][2]
MDA has a long history of psychotherapeutic and recreational use that predates that of MDMA, dating back to at least the mid-1960s.[4][7][5] It has been described as the first entactogen.[3] MDA has also been described as probably the most popular analogue of MDMA.[7] In most countries, the drug is a controlled substance and its possession and sale are illegal.
Use and effects
MDA is bought, sold, and used as a recreational drug due to its enhancement of mood and empathy.[8] It produces MDMA-like effects, including entactogenic and stimulant effects, as well as mild psychedelic effects.[3][9][10][2]
The dose range of MDA given in Alexander Shulgin‘s book PiHKAL (Phenethylamines I Have Known and Loved) and other sources is 80 to 160 mg.[6][4] A wider recreational dose range for MDA of 20 to 200 mg or more, with a typical dose estimate of 90 mg, has also been reported.[11] The dose range of MDA is very similar to that of MDMA.[6][4][11][3]
The effects of MDA include euphoria, empathy, emotional amplification, relaxation, feeling at peace with the world, increased introspection, self-awareness, and acceptance, authenticity, clarity of thought, a desire to communicate with others and relate personal issues, and emotional bonding with others.[4][12][13] These effects led to MDA being called the “love drug” or “hug drug”.[12][6] MDA also produces mild psychedelic effects, including brightened colors, closed-eye visuals or complex mental imagery, synaesthesia, and rarely mild hallucinations.[4][3] It does not produce profound sensory disruption or overt hallucinations.[12][13] In any case, the drug has still been found to produce mystical or spiritual experiences.[9][3]
MDA shares most of MDMA’s qualitative and emotional effects, including entactogenic and stimulant effects.[4][13][3] However, it has been said to be slightly less stimulating than MDMA.[4][3] Conversely, a clinical study found that it was more stimulating than MDMA.[2] In addition, MDA’s hallucinogenic effects are much greater than those of MDMA, although still less than those of classical psychedelics like psilocybin.[4][12][3][2] Another difference between the two drugs is that MDA appears to produce a more introverted and emotionally intense prosocial state, while MDMA encourages a more extroverted and gregarious prosocial state.[3] MDA produces more negative “bad drug effects” and fear than MDMA.[2]
Besides its psychoactive effects, MDA produces sympathomimetic effects such as increased heart rate and blood pressure, among other physiological effects.[7][13][3]
In terms of the individual enantiomers of MDA, (R)-MDA produces psychedelic effects and some entactogenic effects, while (S)-MDA is non-hallucinogenic, produces similar entactogenic effects as the racemate, and has considerable stimulant effects.[12][13][6] High doses of enantiopure (R)-MDA, in the range of 120 to 200 mg, are described as closely resembling the effects of LSD, for instance doses of 200 to 400 μg.[13][14] Enantiopure (R)-MDA at high doses produces more robust psychedelic effects than typical doses of racemic MDA.[13][14][6]
The duration of MDA is about 5 to 8 hours and is about 2 hours longer than that of MDMA (3–6 hours).[4][3][2] Shulgin originally gave a duration of MDA of 8 to 12 hours in PiHKAL, but he later revised this down to only 3 to 6 hours.[6] Modern clinical studies have given an average duration of 6 to 8 hours with a range of 0.9 to 10 hours.[3][2] The drug’s onset is 0.7 hours (range 0.3 to 1.1 hours) and its time to peak effects is 2.0 hours (range 1.0 to 3.5 hours
Political parties
- Meghalaya Democratic Alliance (2003–2008), in India
- Meghalaya Democratic Alliance (2018–present), in India
- Movement for Democracy in Africa, in Burkina Faso
Businesses and other organizations
- MDA (company), a Canadian space technology company
- Magen David Adom, Israel’s emergency medical, disaster, ambulance and blood bank service
- Malaysia Design Archive, a non-profit private organization
- Media Development Authority, in Singapore
- Medical Devices Agency, now part of Medicines and Healthcare products Regulatory Agency, in the UK
- Minnesota Department of Agriculture, in the U.S.
- Missile Defense Agency, an agency of the U.S. Department of Defense
- Muscular Dystrophy Association, an American organization
- Museum Documentation Association, now Collections Trust, a British charity
- Myanmar Dental Association, a professional association
People
Science and technology
Computing and electronics
- MDA framework (Mechanics-Dynamics-Aesthetics), a tool used to analyze games
- Message delivery agent, software to route e-mails
- Mechanical design automation, a branch of computer-aided design
- Microconnect distributed antenna, a kind of transmitter/receiver
- T-Mobile MDA (Mobile Digital Assistant), a mobile phone
- Model-driven architecture, a software design approach
- IBM Monochrome Display Adapter, a video display card and computer display standard
Chemistry
- 3,4-Methylenedioxyamphetamine, known as MDA, a recreational drug
- 4,4′-Methylenedianiline, an industrial chemical
- Malondialdehyde, an organic compound
- Medium-density amorphous ice, a phase of ice
- Metal deactivator or metal deactivating agent, stabilising fuel additive
Other uses in science and technology
- MDa, mega Dalton (unit), a non-SI unit of mass
- Mass drug administration
- Mean directional accuracy, a measure of prediction accuracy of a forecasting method in statistics
- Mesocyclone detection algorithm
- Minimum detectable activity, in whole-body counting measuring radioactivity
- Multiple discriminant analysis, a multivariate dimensionality reduction technique
- Multiple displacement amplification, a DNA amplification technique
Other uses
- Moldova, a country in Europe, ISO 3166-1 country code MDA
- MDA (TV series), an Australian TV show
- MD&A, management discussion and analysis, part of a financial statement
- Maritime domain awareness, understanding the maritime domain that could impact security, safety, economy, or environment
- Master of Defence Administration, a degree awarded by Cranfield School of Management
- Methods, data, analyses, academic journal for survey methodology
- Minimum descent altitude in an instrument approach in aviation
- Mada language, ISO 939-3 language code mda
- Leica MDa, a variant of the Leica M1 camera
See also
- All pages with titles beginning with MDA
- All pages with titles containing MDA
- Misuse of Drugs Act (disambiguation)
- Missionary Diocese of All Saints (MDAS)
- MDA5, melanoma differentiation-associated protein 5
- 2,3-Methylenedioxyamphetamine (2,3-MDA), an amphetamine drug
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