Buy N-t-BOC-MDMA Cas 1228259-70-8

Buy N-t-BOC-MDMA Cas 1228259-70-8

Buy N-t-BOC-MDMA Cas 1228259-70-8

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Buy N-t-BOC-MDMA Cas 1228259-70-8

Buy N-t-BOC-MDMA Cas 1228259-70-8

N–t-BOC-MDMA is a chemical compound which can be both a synthetic precursor to, or a prodrug of the empathogenic drug MDMA. It was first identified in Australia in 2015 as a seizure by customs, and has subsequently been found in China, the Netherlands and other European countries. Originally it was thought to be intended as a non-illegal form of MDMA which could be easily converted into the prohibited final product after importation, however one seizure by police found N–t-BOC-MDMA in the process of being pressed into pills, and experiments with simulated gastric fluid confirmed that it can be broken down to MDMA by human stomach acid. Similar N-protected compounds such as N–t-BOC-methamphetamine, N–p-tosyl-methamphetamine, N–t-BOC-ketamine, N–t-BOC-norketamine, and N-methoxycarbonyl-MDA have also been encountered by law enforcement Buy N-t-BOC-MDMA Cas 1228259-70-8

 

N-t-Boc-mdma

PubChem CID
46237878
Structure
N-t-Boc-mdma_small.png
N-t-Boc-mdma_3D_Structure.png
Molecular Formula
Synonyms
  • N-t-Boc-mdma
  • 1228259-70-8
  • DZ4398X4QR
  • 1,1-Dimethylethyl N-(2-(1,3-benzodioxol-5-yl)-1-methylethyl)-N-methylcarbamate
  • Carbamic acid, N-(2-(1,3-benzodioxol-5-yl)-1-methylethyl)-N-methyl-, 1,1-dimethylethyl ester
Molecular Weight Buy N-t-BOC-MDMA Cas 1228259-70-8
293.36 g/mol
Computed by PubChem 2.2 (PubChem release 2025.04.14)
Dates
Buy N-t-BOC-MDMA Cas 1228259-70-8
Buy N-t-BOC-MDMA Cas 1228259-70-8
Buy N-t-BOC-MDMA Cas 1228259-70-8
Buy N-t-BOC-MDMA Cas 1228259-70-8
Buy N-t-BOC-MDMA Cas 1228259-70-8
Buy N-t-BOC-MDMA Cas 1228259-70-8
Buy N-t-BOC-MDMA Cas 1228259-70-8
Buy N-t-BOC-MDMA Cas 1228259-70-8

 

 

  1. Buy N-t-Boc-mdma (EVT-1470762) | 1228259-70-8 – 

    Compound Description: N-tert-butoxycarbonyl-pseudoephedrine (t-BOC-pseudoephedrine) is a t-BOC protected derivative of pseudoephedrine. Relevance: This compound also belongs to the …

  2. Di-tert-butyl dicarbonate = 98.0 GC 24424-99-5 – MilliporeSigma

    Di-tert-butyl dicarbonate (Boc 2 O) has been used in the synthesis of: An azobenzene amino acid(aa). N-tert-butoxycarbonyl-3,4-methylenedioxymethamphetamine (t-BOC-MDMA) from …

     

  3. N-t-BOC-MDMA – Wikipedia

    N-t-BOC-MDMA is a chemical compound which can be both a synthetic precursor to, or a prodrug of the empathogenic drug MDMA. It was first identified in Australia in 2015 as a seizure by …

     

  4. N-t-Boc-mdma | C16H23NO4 | CID 46237878 – PubChem

    N-t-Boc-mdma | C16H23NO4 | CID 46237878 – structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity …

     

  5. Di-tert-butyl dicarbonate, >=9 | 34660-100G-F | SIGMA-ALDRICH

    Di-tert-butyl dicarbonate (Boc 2 O) is a reagent mainly used for the introduction of the Boc protecting group to amine functionalities. It is also used as a dehydrating agent in some …

  6. Di-tert-butyl dicarbonate, >=98.0% (GC) – Thomas Scientific

    Shop MilliporeSigma Di-tert-butyl dicarbonate, >=98.0% (GC) at Thomas Scientific, your trusted partner in Science.

  7. 3,4-MDMA tert-butyl Carbamate (CAS 1228259-70-8) – Cayman …

    3,4-MDMA tert-butyl Carbamate: An Analytical Reference Standard. CAS Number: 1228259-70-8. Synonyms: t-BOC-3,4-MDMA, N-t-Butoxycarbonyl-MDMA, 3,4-MDMA t-butyl Carbamate, 3,4 …

  8. Buy t-Boc-N-Amido-PEG5-Ms (EVT-2520402) | 2128735-28-2

    N-tert-butoxycarbonyl-MDMA (t-BOC-MDMA) Compound Description: N-tert-butoxycarbonyl-MDMA (t-BOC-MDMA) is a derivative of the illicit drug 3,4-methylenedioxymethamphetamine …

  9. ≥98.0% (GC), for peptide synthesis | Sigma-Aldrich – MilliporeSigma

    Boc-L-Dmt-OH as a fully N,S-blocked cysteine derivative for peptide synthesis by prior thiol capture. Facile conversion of N-terminal Boc-L-Dmt-peptides to H-Cys(Scm)-peptides

     

  10. Buy (Di-tert-butoxycarbonyl)acetylamine (EVT-1628994) | 1588441 …

    Compound Description: N-tert-butoxycarbonyl-MDMA (t-BOC-MDMA) is a derivative of the illicit drug MDMA (3,4-methylenedioxymethamphetamine). It has been identified as a new potential

    (Di-tert-butoxycarbonyl)acetylamine

    Catalog Number: EVT-1628994
    CAS Number: 1588441-36-4
    Molecular Formula: C12H21NO5
    Molecular Weight: 259.3 g/mol
    The product is for non-human research only. Not for therapeutic or veterinary use.
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    Product Introduction

    Compound Description: N-tert-butoxycarbonyl-MDMA (t-BOC-MDMA) is a derivative of the illicit drug MDMA (3,4-methylenedioxymethamphetamine). It has been identified as a new potential MDMA precursor, as it can be readily converted to MDMA under acidic conditions []. This derivatization approach is suggested as a method to conceal the drug during distribution and importation []. Studies also suggest t-BOC-MDMA might act as a pro-drug, converting to MDMA in simulated gastric juice [].

    N1,N2-Di(tert-butoxycarbonyl)-1,2,4-triaminobutane

    Compound Description: N1,N2-Di(tert-butoxycarbonyl)-1,2,4-triaminobutane is a valuable reagent in synthesizing hydrocarbon-bridged bis(ethylenediamine) ligands []. These ligands find application in coordinating metal ions to form complexes with unique properties. The compound is synthesized by reacting 1,2,4-triaminobutane with di-tert-butyl dicarbonate.

    N-tert-butoxycarbonyl-α,ω-Alkanediamines

    Compound Description: N-tert-butoxycarbonyl-α,ω-alkanediamines represent a class of compounds where a tert-butoxycarbonyl (Boc) group protects one amine group of an α,ω-alkanediamine. The length of the alkane chain (represented by χ) can vary. This protection strategy is advantageous in organic synthesis, allowing for selective reactions at the unprotected amine [].

    Di-tert-butyl N-[2,6-bis(methoxymethoxy)phenyl]iminodiacetate

    Compound Description: Di-tert-butyl N-[2,6-bis(methoxymethoxy)phenyl]iminodiacetate was unexpectedly synthesized during research focused on developing platensimycin analogues as antibacterial agents []. This compound features two tert-butoxycarbonyl (Boc) groups attached to the nitrogen of an aniline derivative.

    Overview

    (Di-tert-butoxycarbonyl)acetylamine is a chemical compound that falls under the category of amides and is notable for its protective group functionalities in organic synthesis. It is derived from acetylamine through the introduction of two tert-butoxycarbonyl (Boc) groups, which are commonly used to protect amine functionalities during chemical reactions. This compound is particularly significant in the field of medicinal chemistry and peptide synthesis, where the protection and subsequent deprotection of amines are crucial for the successful synthesis of complex molecules.

    Source and Classification

    The primary source for (Di-tert-butoxycarbonyl)acetylamine is di-tert-butyl dicarbonate, a widely used reagent in organic synthesis known for its ability to introduce Boc groups to amines. This compound can be classified as a derivative of acetylamine, specifically an N,N-di-Boc-acetylamine. In terms of its chemical structure, it features two tert-butoxycarbonyl groups attached to the nitrogen atom of acetylamine, which enhances its stability and reactivity in various synthetic pathways.

    Synthesis Analysis

    Methods

    The synthesis of (Di-tert-butoxycarbonyl)acetylamine typically involves the reaction of acetylamine with di-tert-butyl dicarbonate. The reaction can be conducted under mild conditions, often utilizing a base such as triethylamine to facilitate the formation of the Boc-protected product.

    Technical Details

    1. Reagents:
      • Acetylamine
      • Di-tert-butyl dicarbonate
      • Base (e.g., triethylamine)
    2. Procedure:
      • Dissolve acetylamine in an appropriate solvent (commonly dichloromethane).
      • Add di-tert-butyl dicarbonate and a base while stirring at room temperature.
      • Allow the reaction to proceed for several hours until completion.
      • The product can be purified through standard techniques such as column chromatography.

    This method is efficient and provides good yields of (Di-tert-butoxycarbonyl)acetylamine, making it suitable for laboratory-scale applications.

    Molecular Structure Analysis

    Structure

    The molecular formula for (Di-tert-butoxycarbonyl)acetylamine is C12H23N2O4. The structure consists of:

    • Two tert-butoxycarbonyl groups attached to the nitrogen atom.
    • An acetyl group connected to the nitrogen.

    Data

    The compound’s molecular weight is approximately 243.32 g/mol. Its structural representation highlights the presence of carbon, nitrogen, and oxygen atoms in a specific arrangement conducive to its reactivity and stability.

    Chemical Reactions Analysis

    Reactions

    (Di-tert-butoxycarbonyl)acetylamine can participate in various chemical reactions typical for amides and Boc-protected compounds. Notably:

    • Deprotection: The Boc groups can be removed using strong acids such as trifluoroacetic acid, regenerating the free amine functionality.
    • Coupling Reactions: It can serve as an intermediate in peptide synthesis by coupling with other amino acids or peptide fragments.

    Technical Details

    The reactions involving (Di-tert-butoxycarbonyl)acetylamine often require careful control of conditions to prevent unwanted side reactions, especially during deprotection steps where sensitive functional groups may be present.

    Mechanism of Action

    The mechanism by which (Di-tert-butoxycarbonyl)acetylamine acts primarily revolves around its ability to protect amine functionalities during synthetic processes. The Boc groups shield the amine from nucleophilic attack, allowing chemists to perform other modifications on adjacent functional groups without interference.

    1. Protection: The introduction of Boc groups prevents unwanted reactions with electrophiles.
    2. Deprotection: Upon treatment with acids, the Boc groups are cleaved, regenerating active amines suitable for further reactions.

    This dual functionality makes it a valuable tool in organic synthesis and medicinal chemistry.

    Physical and Chemical Properties Analysis

    Physical Properties

    • Appearance: Typically a colorless or light yellow viscous liquid.
    • Solubility: Soluble in organic solvents such as dichloromethane and ethyl acetate but insoluble in water due to its hydrophobic nature.

    Chemical Properties

    Relevant data indicate that compounds like (Di-tert-butoxycarbonyl)acetylamine are critical intermediates in various synthetic pathways due to their favorable reactivity profiles.

    Applications

    (Di-tert-butoxycarbonyl)acetylamine finds extensive applications in:

    • Peptide Synthesis: Used as a protecting group for amino acids during solid-phase peptide synthesis.
    • Medicinal Chemistry: Serves as an intermediate in the development of pharmaceutical compounds where selective protection of amines is necessary.
    • Organic Synthesis: Employed in various synthetic routes that require temporary protection of amine functionalities.

    Properties

    CAS Number

    1588441-36-4

    Product Name

    (Di-tert-butoxycarbonyl)acetylamine

    IUPAC Name

    tert-butyl N-acetyl-N-[(2-methylpropan-2-yl)oxycarbonyl]carbamate

    Molecular Formula

    C12H21NO5

    Molecular Weight

    259.3 g/mol

    InChI

    InChI=1S/C12H21NO5/c1-8(14)13(9(15)17-11(2,3)4)10(16)18-12(5,6)7/h1-7H3

    InChI Key

    JRIWBSVVECUGGL-UHFFFAOYSA-N

    SMILES

    CC(=O)N(C(=O)OC(C)(C)C)C(=O)OC(C)(C)C

    Canonical SMILES

    CC(=O)N(C(=O)OC(C)(C)C)C(=O)OC(C)(C)C

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