Buy Psilocin (4-HO-DMT) Cas-520-53-6

Buy Psilocin (4-HO-DMT) Cas-520-53-6

Psilocin, also known as 4-hydroxy-N,N-dimethyltryptamine (4-HO-DMT), is a psychedelic drug and fungal alkaloid of the tryptamine and 4-hydroxytryptamine families.^[8][9][2] Along with its phosphate ester psilocybin, it is found in most species of psilocybin-containing mushrooms, such as Psilocybe cubensis and Psilocybe mexicana, and is the compound responsible for their hallucinogenic effects, although concentrations of psilocin are variably lower than those of psilocybin.^[5][9][10] The drug is taken orally and its effects include perceptual changes and visual effects, emotional changes, ego dissolution, time dilation, and mystical experiences, among others.^[2][11][12] Psilocybin, as well as synthetic acyl esters such as 4-AcO-DMT (psilacetin; O-acetylpsilocin) and 4-PrO-DMT (O-propionylpsilocin), are prodrugs of psilocin and have similar properties and effects.Buy Psilocin (4-HO-DMT) Cas-520-53-6 ^[8][13][2]

Psilocin acts as a non-selective serotonin receptor agonist, including of the serotonin 5-HT_2A receptor among others.^[14] The drug produces its hallucinogenic effects specifically via activation of the serotonin 5-HT_2A receptor.^[15][16][17] However, other serotonin receptors, such as the serotonin 5-HT_1A and 5-HT_2C receptors, may also contribute to its effects.^[18][19][20] Notable analogues of psilocin include dimethyltryptamine (DMT), its positional isomer bufotenin (5-HO-DMT), its higher homologue 4-HO-MET (metocin), and others.^[2]

Psilocin and psilocybin were discovered via isolation from psilocybin-containing mushrooms by Albert Hofmann in 1958.^[8][21][22] This followed the Western re-discovery of psilocybin-containing mushrooms by Robert Gordon Wasson and Valentina Pavlovna Wasson in Mexico in 1955.^[21][22] Psilocin, in the form of psilocybin, psilocybin-containing mushrooms, and other prodrugs such as 4-AcO-DMT, is a widely used entheogen as well as recreational psychedelic drug.^[21][8][23] Psilocybin and psilocin became controlled substances in the United States and internationally under the United Nations in 1971.^[24][25] Since then, psilocin, as the active form of psilocybin, has become of interest for potential use in medicine to treat psychiatric disorders such as depression.^[21][23][26] Psilocybin was approved for such purposes in Australia in 2023^[27][28] and is in late-stage clinical trials in the United States and other countries. Buy Psilocin (4-HO-DMT) Cas-520-53-6

Psilocin is used recreationally, spirituality or shamanically, and medically. It is most commonly used in the form of its prodrugs such as psilocybin and 4-AcO-DMT (psilacetin). However, psilocin may also be used itself, either in the form of psilocybin-containing mushrooms (which variably contain psilocin up to similar amounts as psilocybin) or in synthetic form. Buy Psilocin (4-HO-DMT) Cas-520-53-6

Psilocin is usually used orally, but may also be taken intravenously. In terms of dose, it is slightly more potent than psilocybin, about 1.4-fold so (i.e., 1.4 mg psilocybin equals about 1.0 mg psilocin).^[5][32][33] This is related to psilocin’s lack of ester prodrug moiety, which results in its molecular weight being about 40% lower than that of psilocybin (204 g/mol and 284 g/mol, respectively).^[32][34][33] The human dose of psilocin has been given as 10 to 20 mg orally. Buy Psilocin (4-HO-DMT) Cas-520-53-6

In his book TiHKAL (Tryptamines I Have Known and Loved), Alexander Shulgin described the properties and effects of psilocin, either as psilocin itself, as a prodrug like psilocybin or 4-AcO-DMT, or as Psilocybe cubensis mushrooms.^[2] The dose, regardless of form, was listed as 10 to 20 mg orally and the duration as 3 to 6 hours.^[2] The onset, in the case of psilocin specifically, was 15 to 40 minutes.^[2] The perceptual and related effects included brightened colors, increased visual contrast, closed-eye visuals such as patterns, textures, and colors, open-eye visuals such as colors, distortions, and movement, pareidolia, increased appreciation of scenery, perceiving beauty, and enhanced imagination.^[2] Other effects variably included feeling intoxicated, high, and/or stimulated, feelings of peacefulness and serenity, emotional amplification, mood swings, feelings of neuroticism and introversion, feelings of despair, apathy, and unpleasantness, anxiety, confusion, distractibility, impairment, and feeling heavy and tired.^[2] Side effects included chills, nausea, vomiting, and motion sickness, but no hangover.^[2]

In other reports, the effects observed after ingestion of psilocin can include but are not limited to tachycardia, dilated pupils, restlessness or arousal, euphoria, open and closed eye visuals (common at medium to high doses), synesthesia (e.g. hearing colors and seeing sounds), increased body temperature, headache, sweating and chills, and nausea.^[1]

There has been no direct lethality associated with psilocin.^[36][37] There has been no reported withdrawal syndrome when chronic use of this drug is ceased.^[36][38] There is cross tolerance among psilocin, mescaline, lysergic acid diethylamide (LSD), and other psychedelics due to downregulation of these receptors. Buy Psilocin (4-HO-DMT) Cas-520-53-6

Pharmacology

Properties

form powder

InChI key

SPCIYGNTAMCTRO-UHFFFAOYSA-N

InChI

1S/C12H16N2O/c1-14(2)7-6-9-8-13-10-4-3-5-11(15)12(9)10/h3-5,8,13,15H,6-7H2,1-2H3

SMILES string

CN(C)CCc1c[nH]c2cccc(O)c12 Buy Psilocin (4-HO-DMT) Cas-520-53-6

drug control

USDEA Schedule I; Home Office Schedule 1; stupéfiant (France); kontrollierte Droge in Deutschland; regulated under CDSA – not available from Sigma-Aldrich Canada; psicótropo (Spain); Decreto Lei 15/93: Tabela IIA (Portugal); Pszichotróp anyag / Psychotropic Substance (Hungary), 78/2022. (XII. 28.) BM rendelet, kontrollierte Droge in Deutschland

Quality Level

200

Gene Information

human … HTR1A(3350)
rat … Htr2a(29595), Htr2c(25187)

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

application(s)

forensics and toxicology
pharmaceutical (small molecule)
veterinary

storage temp.

−20°C

Description

Biochem/physiol Actions

Hallucinogen originally isolated from the mushroom, Psilocybe mexicana, non-selective serotonin receptor agonist.

Hallucinogen; non-selective serotonin receptor agonist.

Legal Information

German
Dieses Produkt fällt unter das Betäubungsmittelgesetz (BtMG). Für eine Bestellung dieses Produktes ist eine Erlaubnis nach § 3 BtMG zwingend erforderlich, es sei denn, es greift eine Ausnahme von der Erlaubnispflicht nach § 4 oder § 26 BtMG.

English
This product is subject to the German Narcotics Act. A permit under Section 3 of the German Narcotics Act is mandatory for ordering this product unless an exemption from the permit requirement under Section 4 or Section 26 of the German Narcotics Act applies.

Safety Information

pictograms

GHS07

signalword

Warning

hcodes

H302

Hazard Classifications

Acute Tox. 4 Oral

Storage Class

11 – Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

Psilocin

 

Psilocin
Systematic (IUPAC) name
4-Hydroxy-N,N-dimethyl-tryptamine
Identifiers
CAS number	520-53-6
ATC code	?
PubChem	4980
Chemical data
Formula	C12H16N2O
Mol. mass	204.27 g/mol
SMILES	search in eMolecules, PubChem
Physical data
Melt. point	173–176 °C (343–349 °F)
Pharmacokinetic data
Bioavailability	?
Metabolism	Liver
Half life	2-3 hours
Excretion	Kidneys/Urine
Therapeutic considerations
Pregnancy cat.	?
Legal status	Prohibited (S9)(AU) Schedule III(CA) Class A(UK) Schedule I(US)
Routes	Oral, IV

Psilocin (4-HO-DMT) sometimes also (mis)spelled psilocine, psilocyn, or psilotsin, is a psychedelic (hallucinogenic) mushroom alkaloid. It is found in most psychedelic mushrooms together with its phosphorylated counterpart psilocybin. Psilocin is a Schedule I drug under the Convention on Psychotropic Substances.^[1]

Product highlight

Mobile metal analysis: reliable, simple quality control in laboratory quality

Multiparameter measurement redefined – simultaneous GxP-compliant measurement of up to 4 parameters

diaLIMS – more than just comprehensive laboratory software

Contents 1 History 2 Chemistry 3 Pharmacology 4 See also 5 References

History

The Swiss chemist Albert Hofmann and the laboratory assistant Hans Tscherter from Sandoz isolated psilocin and its phosphate ester psilocybin from Psilocybe mushrooms in 1959 guided by self-administration.

Chemistry

Psilocin can be obtained by dephosphorylation of natural psilocybin under strongly acidic or under alkaline conditions (hydrolysis). Another synthetic route uses the Speeter-Anthony tryptamine synthesis starting from 4-hydroxyindole.

Psilocin is relatively unstable in solution due to its phenolic OH group. In the presence of oxygen it readily forms bluish and dark black degradation products. Similar products are also formed under acidic conditions in the presence of oxygen and Fe³⁺ ions (Keller’s reagent, FeCl₃ / MeOH / HCl).

Pharmacology

Psilocin is the pharmacologically active agent in the body after ingestion of psilocybin or psychedelic mushrooms.

Psilocybin is rapidly dephosphorylated in the body to psilocin which acts as a 5HT_2A, 5HT_2C and 5HT_1A agonist. It’s effects are thought to come from it’s ability to mimic serotonin (5-HT) and thereby activate serotonin receptors in the brain.

Psilocin has no significant effect on dopamine receptors (unlike LSD) and only affects the norephenephrine system at very high dosages.^[2]

Psilocin half-life ranges from 2 to 3 hours.^[3]

See psilocybin for more details.

See also

• Psychedelic mushrooms
• Psilocybin
• Tryptamine
• Indole
• Psychedelic drug
• Psychoactive drug

References

1. ^ “Green list”
2. ^ Psilocybin Investigator’s Brochure
3. ^ Psilocybin Investigator’s Brochure

v • d • e Drugs from TiHKAL

AL-LAD • DBT • DET • DiPT • 5-MeO-α-MT • DMT • 2,α-DMT • α,N-DMT • DPT • EiPT • α-ET • ETH-LAD • Harmaline • Harmine • 4-HO-DBT • 4-HO-DET • 4-HO-DiPT • 4-HO-DMT • 5-HO-DMT • 4-HO-DPT • 4-HO-MET • 4-HO-MiPT • 4-HO-MPT • 4-HO-pyr-T • Ibogaine • LSD • MBT • 4,5-MDO-DiPT • 5,6-MDO-DiPT • 4,5-MDO-DMT • 5,6-MDO-DMT • 5,6-MDO-MiPT • 2-Me-DET • 2-Me-DMT • Melatonin • 5-MeO-DET • 5-MeO-DiPT • 5-MeO-DMT • 4-MeO-MiPT • 5-MeO-MiPT • 5,6-MeO-MiPT • 5-MeO-NMT • 5-MeO-pyr-T • 6-MeO-THH • 5-MeO-TMT • 5-MeS-DMT • MiPT • α-MT • NET • NMT • PRO-LAD • pyr-T • Tryptamine • Tetrahydroharmine • α,N,O-TMS

v • d • e Tryptamines

4-Acetoxy-DET • 4-Acetoxy-DIPT • 4-Acetoxy-DMT • 4-HO-DIPT • 5-Bromo-DMT • 5-Fluoro-α-MT • 5-MeO-α-ET  • 5-MeO-α-MT • 5-MeO-DALT • 5-MeO-DET • 5-MeO-DIPT • 5-MeO-DMT • 5-MeO-DPT • 5-MeO-MIPT • α-ET • α-MT • Baeocystin • Bufotenin • DET • DiPT • DMT • DPT • Ethocybin • EiPT • Ethocin • Ibogaine • Iprocin • MET • MiPT • Miprocin • Melatonin • NMT • Norbaeocystin • Normelatonin • PiPT • Psilocin • Psilocybin • Rizatriptan • Serotonin • Sumatriptan • Tryptamine • Tryptophan

Categories: Natural tryptamine alkaloids | Psychedelic tryptamines | Organophosphates | Mycotoxins | Serotonin receptor agonists

1. Psilocin (CAS 520-53-6) – Cayman Chem

   Psilocin: An Analytical Reference Standard. CAS Number: 520-53-6. Synonyms: 4-hydroxy-N,N-Dimethyltryptamine, 4-hydroxy DMT. Purity: ≥95%.
2. Psilocin | CAS No- 520-53-6 | Simson Pharma Limited

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   Psilocin 520-53-6 – MilliporeSigma

   The fully automated system of single drop microextraction coupled with capillary electrophoresis (SDME-CE) was developed for in-line preconcentration and determination of muscimol (MUS) and psilocin …

3. Psilocin | C12H16N2O | CID 4980 – PubChem

   Psilocin is a tryptamine alkaloid that is N, N -dimethyltryptamine carrying an additional hydroxy substituent at position 4. A hallucinogenic alkaloid isolated in …
4. PSILOCIN CAS#: 520-53-6 – ChemicalBook

   Psilocin is the 4-hydroxy analog of Psilocybin, formed by metabolic dephosphorylation of Psilocybin and is an active neurochemical. Psychomimetic. Controlled substance (hallucinogen). An indole …

   • CAS: 520-53-6
   • MW: 204.27

   • MF: C12H16N2O
   • Product Name: PSILOCIN
5. …

6. Psilocin 520-53-6 – MilliporeSigma

   Hallucinogenic fungi synthesize two controlled substances, psilocin and psilocybin. Possession of the fungal species that contain these compounds is a criminal offence in North America.

7. Psilocin 520-53-6 – sigmaaldrich.cn

   A permit under Section 3 of the German Narcotics Act is mandatory for ordering this product unless an exemption from the permit requirement under Section 4 or Section 26 of the German Narcotics Act …

8. Psilocin (CRM) (CAS 520-53-6)

   Psilocin (CRM): A Certified Reference Material. CAS Number: 520-53-6. Synonyms: 4-hydroxy-N,N-Dimethyltryptamine, 4-hydroxy DMT.

9. Psilocin (CRM) (CAS 520-53-6) – Cayman Chem

   Psilocin (CRM): A Certified Reference Material. CAS Number: 520-53-6. Synonyms: 4-hydroxy-N,N-Dimethyltryptamine, 4-hydroxy DMT.