Order Methoxetamine (MXE) Cas 1239943-76-0

Order Methoxetamine (MXE) Cas 1239943-76-0

Methoxetamine (MXE) is a dissociative hallucinogen that has been sold as a designer drug.^[5][6] It differs from many dissociatives such as ketamine and phencyclidine (PCP) that were developed as pharmaceutical drugs for use as general anesthetics in that it was designed specifically to increase the antidepressant effects of ketamine.^[6][7]

MXE is an arylcyclohexylamine.^[8] It acts mainly as an NMDA receptor antagonist, similarly to other arylcyclohexylamines like ketamine and PCP.^[8]

MXE is reported to have a similar effect to ketamine.^[1] It was often believed to possess opioid properties due to its structural similarity to 3-HO-PCP,^[6] but this assumption is not supported by data, which shows insignificant affinity for the μ-opioid receptor by the compound.^[8] Recreational use of MXE has been associated with hospitalizations from high and/or combined consumption in the US and UK.^[9][10][11] Acute reversible cerebellar toxicity has been documented in three cases of hospital admission due to MXE overdose, lasting for between one and four days after exposure. Order Methoxetamine (MXE) Cas 1239943-76-0

MXE was designed in part in an attempt to avoid the urotoxicity associated with ketamine abuse; it was thought the compound’s increased potency and reduced dose would limit the accumulation of urotoxic metabolites in the bladder.^[6][7] Like ketamine, MXE has been found to produce bladder inflammation and fibrosis after high dose chronic administration in mice, although the dosages used were quite large.^[12] Reports of urotoxicity in humans have yet to appear in the medical literature.^[6]

Methoxetamine^[13][8]

Site	Ki (nM)	Action	Species	Ref
NMDA (PCP)	259	Antagonist	Human	[8]
MORTooltip μ-Opioid receptor	>10,000	ND	Human	[8]
DORTooltip δ-Opioid receptor	>10,000	ND	Human	[8]
KORTooltip κ-Opioid receptor	>10,000	ND	Human	[8]
NOPTooltip Nociceptin receptor	>10,000	ND	Human	[8]
σ1	>10,000	ND	Guinea pig	[8]
σ2	>10,000	ND	Rat	[8]
D2	>10,000	ND	Human	[8]
5-HT2A	>10,000	ND	Human	[8]
SERTTooltip Serotonin transporter	481 2,400 (IC50)	Inhibitor	Human	[8] [14]
NETTooltip Norepinephrine transporter	>10,000 20,000 (IC50)	Inhibitor	Human	[8] [14]
DATTooltip Dopamine transporter	>10,000 33,000 (IC50)	Inhibitor	Human	[8] [14]
Values are Ki (nM). The smaller the value, the more strongly the drug binds to the site. Order Methoxetamine (MXE) Cas 1239943-76-0, Order Methoxetamine (MXE) Cas 1239943-76-0, Order Methoxetamine (MXE) Cas 1239943-76-0, Order Methoxetamine (MXE) Cas 1239943-76-0, Order Methoxetamine (MXE) Cas 1239943-76-0, Order Methoxetamine (MXE) Cas 1239943-76-0, Order Methoxetamine (MXE) Cas 1239943-76-0, Order Methoxetamine (MXE) Cas 1239943-76-0, Order Methoxetamine (MXE) Cas 1239943-76-0, Order Methoxetamine (MXE) Cas 1239943-76-0, Order Methoxetamine (MXE) Cas 1239943-76-0, Order Methoxetamine (MXE) Cas 1239943-76-0

MXE acts mainly as a selective and high-affinity NMDA receptor antagonist, specifically of the dizocilpine (MK-801) site (K_i = 257 nM).^[8][15] It produces ketamine-like effects.^[15][16] In addition to antagonism of the NMDA receptor, MXE has been found to act as a serotonin reuptake inhibitor (K_i = 479 nM; IC₅₀ = 2,400 nM).^[8][14] Conversely, it shows little or no effect on the reuptake of dopamine and norepinephrine (K_i and IC₅₀ > 10,000 nM).^[8][14] Nonetheless, MXE has been found to activate dopaminergic neurotransmission, including in the mesolimbic reward pathway.^[15] This is a characteristic that it shares with other NMDA receptor antagonists, including ketamine, PCP, and dizocilpine (MK-801).^[15] Animal studies suggest MXE may have rapidly-acting antidepressant effects similar to those of ketamine.^[15][17] A study that assessed binding of MXE at 56 sites including neurotransmitter receptors and transporters found that MXE had K_i values of >10,000 nM for all sites except the dizocilpine site of the NMDA receptor and the serotonin transporter (SERT).^[8]

MXE has a longer duration of action than that of ketamine.^[18]

MXE is an arylcyclohexylamine and a derivative of eticyclidine (PCE). It can also be thought of as the β-Keto-derivative of 3-methoxyeticyclidine (3-MeO-PCE), or the N-ethyl homologue of methoxmetamine (MXM) and methoxpropamine (MXPr). It is closely related structurally to ketamine, and more distantly to PCP.

MXE hydrochloride is soluble in ethanol up to 10 mg/ml at 25 °C.^[19]

A forensic standard of MXE is available, and the compound has been posted on the Forendex website of potential drugs of abuse.

 

Buy Methoxetamine (MXE) Online

• Methoxetamine (abbreviated as MXE) is a novel psychoactive substance that is emerging on the Internet and induces dissociative effects and acute toxicity.
• MXE acts behaviourally as a typical dissociative anesthetic with stimulant and anxiogenic effects at lower doses, sedative/anesthetic effects at higher doses, and as a disruptor of sensorimotor gating.
• Its pharmacological effects have not yet been adequately investigated, but recently published articles show, that MXE differentially affected motor activity, behavior, and emotional states in rats, depending on the dose tested.
• This drug acts mainly as N-methyl-D-aspartate (NMDA) receptor antagonist and a serotonin reuptake inhibitor.

Details about MXE:

• Like other psychoactive drugs, methoxetamine high is described as pleasurable.
• And includes stimulant, relaxant, and dissociative effects.
• MXE has unpredictable and intense side effects. Particularly with higher doses—that are extremely unpleasant both physically and psychologically.
• This is sometimes called an m-hole.
• Hospital reports show that, while people can recover from MXE drug toxicity.
• This recovery period can require several days of hospitalization. Treatment includes detox medication, intravenous fluids, and respiratory support.
• In addition, news stories have blamed several deaths on the consumption of MXE.

Physical properties:

• The hydrochloride salt of methoxetamine is a white, odorless crystalline powder at room temperature.
• A physical description of the freebase form could not be found in the readily accessible literature.

Pharmacology:

• In research examining the pharmacological profile, data suggests that methoxetamine has an affinity for the N-methyl-D-aspartate (NMDA) receptor and acts as an antagonist.
• Also, it is similar to the related ketamine but it has a longer duration of action than ketamine.
• In addition similarly to ketamine, methoxetamine also involves dopamine and serotonin reuptake inhibition.
• No studies have been performed examining the pharmacology and mode of action of methoxetamine in humans.

Pharmacokinetics:

• There are no published formal animal or human studies examining its pharmacokinetic properties.

How to take Methoxetamine?

• It is a drug from the arylcyclohexylamine family of compounds.
• Arylcyclohexylamines also include ketamine and PCP, which are two drugs that have been around for decades.
• And which have been used for anesthesia in humans and animals.
• This drug is a much more recently developed substance, which has been specifically used as a recreational drug.
• MXE differs from ketamine on a molecular level.
• Initial reports indicate that, despite its semi-legal status, it has a longer-lasting and more intense effect than ketamine.

• There have not been any formal studies to demonstrate exactly how it works. But it is assumed to work in the same way that ketamine does, that is, it affects the brain’s neurotransmitters by acting on their receptors.
• One of the neurotransmitters thought to be affected is dopamine, which is associated with feelings of euphoria And has a role in many addictions, including those involving drugs.
• Users report the rapid onset of action (10-20 minutes) following nasal insufflation, rectal, or intravenous/intramuscular administration.
• The sublingual route is reported as less effective, with oral least effective.
• Peak effects are reported to occur between 1-3 hours after exposure with a further duration of between three and six hours during which after-effects are experienced.
• There are a few reports of effects lasting 24 hours; the half-life for clinical effects is three hours.

Effect:

1. Users may experience pleasurable feelings of euphoria and enlightenment for up to 24 hours after using the drug
2. Taking too much or having a bad reaction to this drug may lead to psychiatric, cognitive, neurological, and/or cardiovascular problems.

Legal Status:

• Despite legal restrictions placed on the recreational use of similar drugs, PCP and ketamine.
• There are currently no federal restrictions on the sale of MXE in the United States.

Chemical Formula:

• CAS: 1239943-76-0
• Formula: C15H21NO2
• Molecular weight: 247.33
• IUPAC: (RS)2-(3-methoxyphenyl)-2-(ethylamino)cyclohexanone
• Synonyms: MXE, 3-MeO-2-Oxo-PCE
• Form: Crystal & Powder
• Purity: 99.8%

Where can you buy MXE Online?

• We sell premium quality Methoxetamine with secure payment methods, so feel free to contact us if you have any questions.
• You must be at least 18 years old to buy from us.

Why should you order Methoxetamine online from us?

• Our delivery within the US will take us a maximum of 24 hours while international delivery to other countries will take us 2-4 days…
• We have an amazing customer service

Buy Methoxetamine (MXE) Online
Methoxetamine (abbreviated as MXE) is a novel psychoactive substance that is emerging on the Internet and induces dissociative
effects and acute toxicity.
MXE acts behaviourally as a typical dissociative anesthetic with stimulant and anxiogenic effects at lower doses,
sedative/anesthetic effects at higher doses, and as a disruptor of sensorimotor gating.
Its pharmacological effects have not yet been adequately investigated, but recently published articles show, that MXE differentially
affected motor activity, behavior, and emotional states in rats, depending on the dose tested.
This drug acts mainly as N-methyl-D-aspartate (NMDA) receptor antagonist and a serotonin reuptake inhibitor.
Details about MXE:
Like other psychoactive drugs, methoxetamine high is described as pleasurable.
And includes stimulant, relaxant, and dissociative effects.
MXE has unpredictable and intense side effects. Particularly with higher doses—that are extremely unpleasant both physically and
psychologically.
This is sometimes called an m-hole.
Hospital reports show that, while people can recover from MXE drug toxicity.
This recovery period can require several days of hospitalization. Treatment includes detox medication, intravenous fluids, and
respiratory support.
In addition, news stories have blamed several deaths on the consumption of MXE.
Physical properties:
The hydrochloride salt of methoxetamine is a white, odorless crystalline powder at room temperature.
A physical description of the freebase form could not be found in the readily accessible literature.
Pharmacology:
In research examining the pharmacological profile, data suggests that methoxetamine has an affinity for the N-methyl-D-aspartate (NMDA)
receptor and acts as an antagonist.
Also, it is similar to the related ketamine but it has a longer duration of action than ketamine.
In addition similarly to ketamine, methoxetamine also involves dopamine and serotonin reuptake inhibition.
No studies have been performed examining the pharmacology and mode of action of methoxetamine in humans.
Pharmacokinetics:
There are no published formal animal or human studies examining its pharmacokinetic properties.
How to take Methoxetamine?
It is a drug from the arylcyclohexylamine family of compounds.
Arylcyclohexylamines also include ketamine and PCP, which are two drugs that have been around for decades.
And which have been used for anesthesia in humans and animals.
This drug is a much more recently developed substance, which has been specifically used as a recreational drug.
MXE differs from ketamine on a molecular level.
Initial reports indicate that, despite its se

The qualitative effects of MXE were first described online in May 2010 and the compound became commercially available on a small scale in September 2010.^[5][6] By November the use and sale of the MXE had increased enough for it to be formally identified by the European Monitoring Centre for Drugs and Drug Addiction. By July 2011, the EMCDDA had identified 58 websites selling the compound at a cost of 145–195 euros for 10 grams.^[21]

Mixmag reported in January 2012, that people in the dance music and clubbing community have given MXE the slang name ‘roflcoptr‘.^[22] Vice commented that it was likely that the phrase will only be used by “the same politicians, parents and journalists” who called mephedrone ‘meow meow’.^[23] After being called mexxy in UK Home Office press releases, the media adopted the name.^[11][24]

A literature review was published in March 2012 which looked at scientific literature and information on the web. It concluded that “the online availability of information on novel psychoactive drugs, such as MXE, may constitute a pressing public health challenge. Better international collaboration levels and novel forms of intervention are necessary to tackle this fast-growing phenomenon.”^[25]

MXE became classified as a narcotic in Brazil in February 2014.^[26]

As of January 2011 MXE is a controlled substance in Canada.^[27]

As of October 2015 MXE is a controlled substance in China.^[28]

On 16 June 2014, the European Commission proposed that MXE be banned across the European Union, subjecting those in violation to criminal sanctions. This is following the procedure for risk-assessment and control of new psychoactive substances set up by the council: Decision 2005/387/JHA.^[29]

Scheduled in the “government decree on narcotic substances, preparations and plants” and is hence illegal.^[30]

MXE became classified as an illegal narcotic in Israel in May 2012.^[31][32]

MXE became a controlled substance in Japan from 1 July 2012, by amendment to the Pharmaceutical Affairs Law.^[33][34]

MXE is a controlled substance (group II-P) making it illegal to produce, sell or possess in The Republic of Poland as of 1 July 2015.^[35]

MXE has

Methoxetamine

 

1. Buy Online CAS Number 1239943-76-0 – TRC – Methoxetamine | LGC …

   Purchase online CAS Number 1239943-76-0 – TRC – Methoxetamine. High Quality CRMs, Reference Materials, Proficiency Testing & More at LGC Standards.
2. Buy Methoxetamine (MXE) Online | CAS Number: …

   Buy Methoxetamine (MXE) Online | CAS Number: 1239943-76-0 …
3. Buy Methoxetamine High Purity : Stability & Details

   Discover Methoxetamine (CAS 1239943-76-0) with 98.6% purity and over 2 years stability. Explore its chemical profile now.
4. CAS 1239943-76-0: Methoxetamine | CymitQuimica

   Jun 8, 2013 · Methoxetamine, often abbreviated as MXE, is a synthetic compound that belongs to the class of arylcyclohexylamines, which are known for their dissociative anesthetic properties.

5. Buy 99% Pure Methoxetamine (MXE) Online Discreetly

   We sell premium quality Methoxetamine with secure payment methods, so feel free to contact us if you have any questions. You must be at least 18 years old to buy from us.

6. buy MXE online | Med Chem

   Our prices are among the lowest on the market, just check them by your own. Our company has great experience to export goods, and all packages are sent in completely unmarked envelopes – the …

7. Methoxetamine MXE For Sale – Keta Meds Pharma

   Methoxetamine MXE For sale is highly effective at relieving depression quickly. Often within only a few minutes, and even at doses which produce little …
8. 2- (ethylaMino)-2- (3-Methoxyphenyl)-1-cyclohexanone | 1239943-76-0

   May 15, 2023 · Methoxetamine (MXE) or 3-MeO-2-Oxo-PCE is a chemical of the arylcyclohexylamine class. It is considered an analog of Ketamine (K165300) that also contains structural features of …

9. Methoxetamine｜1239943-76-0｜lookchem

   Base Information Edit Chemical Name:Methoxetamine CAS No.: 1239943-76-0 Molecular Formula:C15H21NO2 Molecular Weight:247.33

10. Methoxetamine – Chemnexis Pharma – Global Supplier of Research …

    We sell premium quality Methoxetamine with secure payment methods, so feel free to contact us if you have any questions. You must be at least 18 years old to buy from us.