Buy Methylethyltryptamine (MET) Cas 5599-69-9

Buy Methylethyltryptamine (MET) Cas 5599-69-9

Methylethyltryptamine (MET), also known as N-methyl-N-ethyltryptamine (N,N-MET), is a psychedelic drug of the tryptamine family.^[1][4] It is taken orally or via inhalation.^[1][3]

The drug acts as an agonist of the serotonin 5-HT₂ receptors and to a lesser extent as a serotonin releasing agent.^[5] It is closely related to dimethyltryptamine (DMT) and to diethyltryptamine (DET).^[6][7]

MET appears to have been first described in the literature in 1981.^[8] It was only briefly mentioned in Alexander Shulgin‘s 1997 book TiHKAL (Tryptamines I Have Known and Loved).^[1] The drug was encountered as a novel designer drug in Europe in 2014.^[9]

MET was briefly mentioned in Alexander Shulgin‘s TiHKAL (Tryptamines I Have Known and Loved) and other publications, where he has stated it to be orally active as a psychedelic at doses of 80 to 100 mg.^[1][4][2] Its duration, onset, and peak were not provided.^[1] The free base of MET has been reported to be active as a psychedelic via vaporization at a dose of 15 mg per informal anecdotal reports.^[2][3] Very little information is available on the effects of MET.^[2] However, its effects have been reported to include hallucinations, euphoria, tactile enhancement, cognitive effects, pupil dilation, muscle cramps, teeth grinding, and increased heart rate and blood pressure.^[2]

MET is a serotonin 5-HT_2A and 5-HT_2C receptor partial agonist.^[5] It shows very weak activity as an agonist of the serotonin 5-HT_1A and 5-HT_2B receptors.^[5] In addition to acting at the serotonin 5-HT₂ receptors, MET is a serotonin releasing agent with lower potency.^[5] It produces the head-twitch response, a behavioral proxy of psychedelic effects, in animals.^[7][5]

MET, also known as N-methyl-N-ethyltryptamine, is a substituted tryptamine derivative.^[1][4][5] It is closely related to N,N-dimethyltryptamine (DMT) and to other N,N-dialkylated tryptamines.^[1][4][5]

Analogues of MET besides DMT include DET, DPT, DiPT, DBT, MiPT, MBT, EPT, EiPT, and PiPT, among others.^[1][4] Derivatives of MET include 4-HO-MET, 5-HO-MET, 5-MeO-MET, bretisilocin (5-fluoro-MET; GM-2505), and 7-F-5-MeO-MET, among others.^[1][4]

MET appears to have first been described in the literature by 1981.^[8] It was specifically mentioned in Michael Valentine Smith’s Psychedelic Chemistry.^[8] Subsequently, MET was briefly described in Alexander Shulgin‘s TiHKAL (Tryptamines I Have Known and Loved) in 1997.^[1] MET was encountered as a novel designer drug in Europe in 2014.^[9]

MET is not a controlled substance in Canada as of 2025.^[10]

MET is not an explicitly controlled substance in the United States.^[11] However, it could be considered a controlled substance under the Federal Analogue Act if intended for human consumption.

• Substituted tryptamine
• Bretisilocin (5-fluoro-MET; GM-2505)