Buy Boldenone (1-Dehydrotestosterone) Cas 846-48-0
Buy Boldenone (1-Dehydrotestosterone) Cas 846-48-0
Boldenone (developmental code name RU-18761), is a naturally occurring anabolic–androgenic steroid (AAS) and the 1(2)-dehydrogenated analogue of testosterone. Boldenone itself has never been marketed; as a pharmaceutical drug, it is used as boldenone undecylenate, the undecylenate ester.[3][4][7]
Side effects
Pharmacology
Pharmacodynamics
Like other AAS, boldenone is an agonist of the androgen receptor (AR).[7] The activity of boldenone is mainly anabolic, with a low androgenic potency. Boldenone will increase nitrogen retention, protein synthesis, increases appetite and stimulates the release of erythropoietin in the kidneys.[8]
Chemistry
Boldenone, also known as Δ1-testosterone, 1-dehydrotestosterone, or androsta-1,4-dien-17β-ol-3-one, is a naturally occurring androstane steroid and a derivative of testosterone.[3][4][7] It is specifically testosterone with a double bond between the C1 and C2 positions.[3][4][7] A related compound is quinbolone, the 17-cyclopentenyl enol ether of boldenone.[3][4]
Sources
Boldenone occurs naturally in the scent gland of Ilybius fenestratus, a species of aquatic beetle.[3]
In calves not fed boldenone, their urine 17α-boldenone content is strictly related to the phytosterol content of the diet. These naturally occurring amounts present are below doping attention limits.[9]
History
Ciba reportedly patented boldenone in 1949.[7] It subsequently developed several experimental esters of the drug in the 1950s and 1960s.[7] One of these was boldenone undecylenate, which was introduced for clinical use under the brand name Parenabol and saw some use in the late 1960s and early 1970s.[7] However, it was discontinued before the end of the 1970s.[7] Subsequently, boldenone undecylenate was introduced by Squibb under the brand name Equipose for veterinary use, most commonly in horses.[7]
Society and culture
Generic names
Boldenone is the generic name of the drug and its INNTooltip International Nonproprietary Name and BANTooltip British Approved Name.[3][4][5][6]
Brand names
Boldenone is marketed as veterinary drug as boldenone undecylenate (a derivative of boldenone) under the following brand names: Boldebal H, Equipoise, and Sybolin.[6] It is marketed as a veterinary combination drug with methandriol under the brand name Drive.[6]
In Ukraine, it is marketed for human consumption as the injectable steroid Boldenol.[10]
Doping in sports
There are many known cases of doping in sports with boldenone undecylenate by professional athletes.
References
In most regions, Boldenone is not approved for human use. It is typically listed as a Schedule III controlled substance in the United States and is subject to similar restrictions globally. Possession or distribution without appropriate licensing is illegal. Furthermore, it is strictly prohibited by the World Anti-Doping Agency (WADA) and other sports organizations due to its performance-enhancing effects.
The use of anabolic steroids like Boldenone without professional medical supervision carries significant health risks, including:
-
- Cardiovascular Issues: Increased risk of heart disease, stroke, and high blood pressure.
- Hormonal Imbalances: Suppression of natural testosterone production, which can lead to infertility and other endocrine complications.
- Organ Damage: Potential for liver toxicity and kidney strain.
- Psychological Effects: Associations with increased aggression, mood swings, and dependency. [1, 2, 3]
CAS Number
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Boldenone (1,4-androstadiene-17β-ol-3-one) is a synthetic anabolic-androgenic steroid defined by a C1-C2 double bond added to the foundational testosterone scaffold. In industrial and laboratory procurement, the unesterified free alcohol form of boldenone is primarily sourced as a high-purity analytical reference standard for anti-doping chromatography, a structural model for in vitro androgen receptor (AR) binding assays, and a critical starting material for the synthesis of long-acting veterinary active pharmaceutical ingredients (APIs). Unlike its formulated ester derivatives, free boldenone offers the precise gravimetric stability and unprotected 17β-hydroxyl group required for custom esterification and baseline pharmacological profiling [1].
Substituting free boldenone with its most common commercial derivative, boldenone undecylenate, fundamentally fails in laboratory workflows due to physical state differences. Boldenone undecylenate is a viscous, oily liquid at room temperature, which precludes precise gravimetric weighing for analytical standards and eliminates the free 17β-hydroxyl group needed for custom chemical synthesis. Furthermore, substituting boldenone with the parent molecule testosterone is unviable for metabolic and receptor studies; the lack of the C1-C2 double bond in testosterone significantly increases its estrogenic conversion rate and alters its downstream metabolic profile, failing to produce the specific 1-dehydro markers required for anti-doping calibration[1].
Physical State and Gravimetric Processability
For analytical and synthetic procurement, the physical state of the starting material dictates handling protocols. Free boldenone is a crystalline solid with a melting point of 164–166 °C, whereas its primary commercial substitute, boldenone undecylenate, is a viscous oily liquid at room temperature. This solid state allows for highly accurate gravimetric weighing and stable storage without the matrix effects or handling challenges associated with viscous oils [1].
| Evidence Dimension | Physical state and melting point |
| Target Compound Data | Crystalline solid (mp 164–166 °C) |
| Comparator Or Baseline | Boldenone undecylenate (Viscous oily liquid at 20–25 °C) |
| Quantified Difference | Solid vs. Liquid state at standard laboratory conditions |
| Conditions | Room temperature (25 °C) handling and preparation |
Solid-state free boldenone is strictly required for precise gravimetric standard preparation and as a viable precursor for custom ester synthesis.
Receptor Binding and Reduced Enzymatic Conversion Profile
In pharmacological modeling, boldenone provides a distinct receptor profile compared to endogenous androgens. The introduction of the C1-C2 double bond significantly reduces its estrogenic activity and 5α-reductase affinity compared to testosterone. This allows researchers to study strong anabolic AR-mediated signaling with a highly reduced rate of conversion into estrogenic or potent dihydrotestosterone-like metabolites [1].
| Evidence Dimension | Estrogenic activity and 5α-reductase conversion |
| Target Compound Data | Low estrogenic activity; extremely low 5α-reductase affinity |
| Comparator Or Baseline | Testosterone (High aromatization and 5α-reduction to DHT) |
| Quantified Difference | Substantial reduction in secondary enzymatic conversions |
| Conditions | In vitro receptor binding and enzymatic assays |
This profile makes boldenone the preferred ligand for AR studies requiring high anabolic signaling with minimal estrogenic or DHT-driven interference.
Metabolic Distinctness for Anti-Doping Calibration
For forensic and sports testing laboratories, boldenone is procured to calibrate analytical equipment for its specific metabolic pathway. The C1-C2 double bond forces a structurally distinct metabolic route, yielding specific 1-dehydro metabolites that are entirely distinct from testosterone’s primary metabolites (androsterone and etiocholanolone). Detecting these specific markers is the definitive standard for identifying boldenone administration in mass spectrometry workflows [1].
| Evidence Dimension | Primary diagnostic urinary metabolite |
| Target Compound Data | Yields specific 1-dehydro metabolites (e.g., 5β-androst-1-en-17β-ol-3-one) |
| Comparator Or Baseline | Testosterone (Yields androsterone and etiocholanolone) |
| Quantified Difference | Complete divergence in primary urinary marker structure |
| Conditions | In vivo metabolism and LC-MS/MS urinalysis |
Procuring the exact boldenone parent compound is mandatory for generating the specific metabolic markers required in accredited WADA and equine anti-doping reference libraries.
Precursor for Custom API Esterification
Because free boldenone possesses an unprotected 17β-hydroxyl group and exists as a processable solid (mp 164–166 °C), it is the mandatory starting material for synthesizing novel lipophilic prodrugs. Industrial chemists use this free base to attach various ester chains, controlling the pharmacokinetic release profile of the resulting veterinary APIs [1].
Analytical Reference Standards for Anti-Doping
In forensic and sports medicine laboratories, free boldenone is utilized as a primary reference standard. It is essential for calibrating GC-MS and LC-MS/MS instruments to detect its specific in vivo 1-dehydro metabolites, ensuring compliance with WADA and equine sports testing protocols [2].
In Vitro Androgen Receptor (AR) Modeling
Due to its structural modification (C1-C2 double bond) that lowers its aromatase and 5α-reductase affinity compared to testosterone, boldenone is heavily utilized in in vitro assays. It serves as a benchmark ligand for studying AR-mediated anabolic pathways in environments where estrogenic cross-reactivity must be minimized [3].
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GHS Hazard Statements
H302 (14.29%): Harmful if swallowed [Warning Acute toxicity, oral];
H315 (14.29%): Causes skin irritation [Warning Skin corrosion/irritation];
H319 (14.29%): Causes serious eye irritation [Warning Serious eye damage/eye irritation];
H351 (78.57%): Suspected of causing cancer [Warning Carcinogenicity];
H360 (78.57%): May damage fertility or the unborn child [Danger Reproductive toxicity];
H362 (78.57%): May cause harm to breast-fed children [Reproductive toxicity, effects on or via lactation];
H412 (78.57%): Harmful to aquatic life with long lasting effects [Hazardous to the aquatic environment, long-term hazard];
Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown.
Pharmacology
MeSH Pharmacological Classification
Mechanism of Action
KEGG Target based Classification of Drugs
Estrogen like receptors
3-Ketosteroid receptor
NR3C4 (AR) [HSA:367] [KO:K08557]
Pictograms
Irritant;Health Hazard
Other CAS
Wikipedia
Biological Half Life
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Dates
2: Chiesa L, Pavlovic R, Dusi G, Pasquale E, Casati A, Panseri S, Arioli F. Determination of α- and β-boldenone sulfate, glucuronide and free forms, and androstadienedione in bovine urine using immunoaffinity columns clean-up and liquid chromatography tandem mass spectrometry analysis. Talanta. 2015 Jan;131:163-9. doi: 10.1016/j.talanta.2014.07.035. PubMed PMID: 25281088.
3: Chiesa L, Nobile M, Panseri S, Sgoifo Rossi CA, Pavlovic R, Arioli F. Detection of boldenone, its conjugates and androstadienedione, as well as five corticosteroids in bovine bile through a unique immunoaffinity column clean-up and two validated liquid chromatography-tandem mass spectrometry analyses. Anal Chim Acta. 2014 Dec 10;852:137-45. doi: 10.1016/j.aca.2014.09.002. PubMed PMID: 25441890.
4: Chiesa L, Nobile M, Panseri S, Vigo D, Pavlovic R, Arioli F. Suitability of bovine bile compared to urine for detection of free, sulfate and glucuronate boldenone, androstadienedione, cortisol, cortisone, prednisolone, prednisone and dexamethasone by LC-MS/MS. Food Chem. 2015 Dec 1;188:473-80. doi: 10.1016/j.foodchem.2015.04.131. PubMed PMID: 26041220.
5: Gómez C, Pozo OJ, Geyer H, Marcos J, Thevis M, Schänzer W, Segura J, Ventura R. New potential markers for the detection of boldenone misuse. J Steroid Biochem Mol Biol. 2012 Nov;132(3-5):239-46. doi: 10.1016/j.jsbmb.2012.05.010. PubMed PMID: 22664392.
6: Hullstein I, Sagredo C, Hemmersbach P. Carbon isotope ratios of nandrolone, boldenone, and testosterone preparations seized in Norway compared to those of endogenously produced steroids in a Nordic reference population. Drug Test Anal. 2014 Nov-Dec;6(11-12):1163-9. doi: 10.1002/dta.1745. PubMed PMID: 25388436.
7: Tousson E, El-Moghazy M, Massoud A, Akel A. Histopathological and immunohistochemical changes in the testes of rabbits after injection with the growth promoter boldenone. Reprod Sci. 2012 Mar;19(3):253-9. doi: 10.1177/1933719111418126. PubMed PMID: 22383777.
8: Granja RH, Salerno AG, de Lima AC, Montalvo C, Reche KV, Giannotti FM, Wanschel AC. Liquid chromatography/tandem mass spectrometry method to determine boldenone in bovine liver tissues. J AOAC Int. 2014 Sep-Oct;97(5):1476-80. doi: 10.5740/jaoacint.13-335. PubMed PMID: 25903003.
9: Destrez B, Bichon E, Rambaud L, Courant F, Monteau F, Pinel G, Antignac JP, Le Bizec B. Criteria to distinguish between natural situations and illegal use of boldenone, boldenone esters and boldione in cattle 2. Direct measurement of 17beta-boldenone sulpho-conjugate in calf urine by liquid chromatography–high resolution and tandem mass spectrometry. Steroids. 2009 Oct;74(10-11):803-8. doi: 10.1016/j.steroids.2009.04.010. PubMed PMID: 19409402.
10: Tousson E, El-Moghazy M, Massoud A, El-Atrash A, Sweef O, Akel A. Physiological and biochemical changes after boldenone injection in adult rabbits. Toxicol Ind Health. 2016 Jan;32(1):177-82. doi: 10.1177/0748233713501365. PubMed PMID: 24081634.
11: Wu X, Gao F, Zhang W, Ni J. Metabolism study of boldenone in human urine by gas chromatography-tandem mass spectrometry. J Pharm Biomed Anal. 2015 Nov 10;115:570-5. doi: 10.1016/j.jpba.2015.08.014. PubMed PMID: 26319750.
12: Toledano RM, Díaz-Plaza EM, Cortes JM, Aragón A, Vázquez AM, Villén J, Muñoz-Guerra J. Development of an analytical method for the determination of the misuse in sports of boldenone through the analysis of urine by on-line coupling liquid chromatography-gas chromatography-combustion-isotope ratio mass spectrometry. J Chromatogr A. 2014 Nov 28;1370:171-8. doi: 10.1016/j.chroma.2014.10.049. PubMed PMID: 25454142.
13: Tousson E. Histopathological alterations after a growth promoter boldenone injection in rabbits. Toxicol Ind Health. 2016 Feb;32(2):299-305. doi: 10.1177/0748233713500821. PubMed PMID: 24097356.
14: Alm-Eldeen A, Tousson E. Deterioration of glomerular endothelial surface layer and the alteration in the renal function after a growth promoter boldenone injection in rabbits. Hum Exp Toxicol. 2012 May;31(5):465-72. doi: 10.1177/0960327111420745. PubMed PMID: 21878449.
15: Van Poucke C, Van Vossel E, Van Peteghem C. Fractionation of free and conjugated steroids for the detection of boldenone metabolites in calf urine with ultra-performance liquid chromatography/tandem mass spectrometry. Rapid Commun Mass Spectrom. 2008 Aug;22(15):2324-32. doi: 10.1002/rcm.3617. PubMed PMID: 18615838.
16: Tousson E, Alm-Eldeen A, El-Moghazy M. p53 and Bcl-2expression in response to boldenone induced liver cells injury. Toxicol Ind Health. 2011 Sep;27(8):711-8. doi: 10.1177/0748233710395350. PubMed PMID: 21421678.
17: Verheyden K, Noppe H, Mortier V, Vercruysse J, Claerebout E, Van Immerseel F, Janssen CR, De Brabander HF. Formation of boldenone and boldenone-analogues by maggots of Lucilia sericata. Anal Chim Acta. 2007 Mar 14;586(1-2):163-70. PubMed PMID: 17386708.
18: Blokland MH, van Rossum HJ, Sterk SS, van Ginkel LA, Stephany RW. Development of a method which discriminates between endogenous and exogenous beta-boldenone. Anal Chim Acta. 2007 Mar 14;586(1-2):147-53. PubMed PMID: 17386706.
19: Le Bizec B, Courant F, Gaudin I, Bichon E, Destrez B, Schilt R, Draisci R, Monteau F, André F. Criteria to distinguish between natural situations and illegal use of boldenone, boldenone esters and boldione in cattle 1. Metabolite profiles of boldenone, boldenone esters and boldione in cattle urine. Steroids. 2006 Dec;71(13-14):1078-87. PubMed PMID: 17084871.
20: Ros MM, Sterk SS, Verhagen H, Stalenhoef AF, de Jong N. Phytosterol consumption and the anabolic steroid boldenone in humans: a hypothesis piloted. Food Addit Contam. 2007 Jul;24(7):679-84. PubMed PMID: 17613052.
Product Description:
Product Name: Boldenone CAS NO: 846-48-0
Synonyms:
1,2-didehydrotestosterone;
Androsta-1,4-dien-3-one, 17-hydroxy-, (17β)-;
dehydrotestosterone;
Chemical & Physical Properties:
Appearance: White to off-white crystalline powder
Assay :≥99.0%
Density: 1.14 g/cm3
Boiling Point: 435.6℃ at 760 mmHg
Melting Point: 164-166℃
Flash Point: 185.8℃
Refractive Index: 1.577
Stability: Stable at normal temperatures and pressures.
Storage Condition: Keep tightly closed.
Safety Information:
RTECS: BV7994400
HS Code: 2942000000
Hazard Codes: F,Xn
Risk Statements: 11-20/21/22-36
Safety Statements: 16-36/37
Boldenone is the chemical precursor of its endecylenate ester prodrug boldenone undecylenate – which is used extensively as a steroid for animals, mainly horses and cattle, under the brand name Equipoise, among others. For this application, it is injected to improve the weight, hair coat, appetite, and general physical condition of horses affected by disease, anorexia, or overwork. It is also used as an illegal doping agent for human athletes. As a derivative of testosterone, it retains its anabolic strength, but exhibits reduced androgenic effects.
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