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6-APB, also known as 6-(2-aminopropyl)benzofuran, is an entactogen of the phenethylamine, amphetamine, and benzofuran families.^[1][2] 6-APB and related drugs are sometimes informally called “Benzofury” in media reports. It is similar in structure to MDA, but differs in that the 3,4-methylenedioxyphenyl ring system has been replaced with a benzofuran ring. 6-APB is also the unsaturated benzofuran derivative of 6-APDB. It may appear as a tan or brown grainy powder.^{[citation needed]}

While the drug never became particularly popular, it briefly entered the rave and underground clubbing scene in the UK before its sale and import were banned. It falls under the category of research chemicals, sometimes called “legal highs” if uncontrolled. Because 6-APB and other substituted benzofurans have not been explicitly outlawed in some countries, they are often technically legal, contributing to its popularity.^{[citation needed] Buy 6-APB (Benzofury) Cas 286834-85-3}

6-APB was first described in the scientific literature in 2000^[3][4][5][6] and emerged as a novel designer drug in 2010.^[4][5][7]

6-APB is reported to produce entactogenic, stimulant, and mild psychedelic effects in humans.^{[4][8] Buy 6-APB (Benzofury) Cas 286834-85-3}

Acute psychosis has been associated with recreational use of 6-APB in combination with the synthetic cannabinoid JWH-122.^{[9] Buy 6-APB (Benzofury) Cas 286834-85-3}

6-APB acts as a serotonin–norepinephrine–dopamine releasing agent (SNDRA), with EC₅₀Tooltip half-maximal effective concentration values for monoamine release of 36 nM for serotonin, 14 nM for norepinephrine, and 10 nM for dopamine in rat brain synaptosomes.^[3][7] Simultaneously, 6-APB is a serotonin–norepinephrine–dopamine reuptake inhibitor (SNDRI), with affinities (K_i) of 117 nM for the norepinephrine transporter (NET), 150 nM for the dopamine transporter (DAT), and 2,698 nM for the serotonin transporter (SERT)^[2] as well as IC₅₀Tooltip half-maximal effective concentration values for monoamine reuptake inhibition of 930 nM for serotonin, 190 nM for norepinephrine, and 3,300 nM for dopamine.^[7]

In addition to actions at the monoamine transporters, 6-APB is a potent high-efficacy partial agonist or full agonist of the serotonin 5-HT_2B receptor (K_i = 3.7 nM; EC₅₀Tooltip half-maximal effective concentration = 140 nM; E_maxTooltip maximal efficacy = 70%).^[2] It has higher affinity for this target than any other site.^[10] Moreover, unlike MDMA, 6-APB shows 100-fold selectivity for the serotonin 5-HT_2B receptor over the serotonin 5-HT_2A and 5-HT_2C receptors in terms of affinity.^[10][6] It is notably both more potent and more selective as an agonist of the serotonin 5-HT_2B receptor than the reference serotonin 5-HT_2B receptor agonist, BW-723C86, which is commonly used for research into the serotonin 5-HT_2B receptor.^{[citation needed]} Although much more potent at the serotonin 5-HT_2B receptor, 6-APB is also a partial agonist of the serotonin 5-HT_2A receptor (EC₅₀ = 5,900 nM; E_max = 43%) and shows affinity for the serotonin 5-HT_2C receptor (K_i = 270 nM) and the serotonin 5-HT_1A receptor (K_i = 1,500 nM).^[7] It has been reported to act as an agonist of the serotonin 5-HT_2C receptor similarly to the serotonin 5-HT_2A and 5-HT_2B receptors.^{[4][11] Buy 6-APB (Benzofury) Cas 286834-85-3}

Besides the serotonin 5-HT₂ receptors, 6-APB has been found to bind with high affinity to the α_2C-adrenergic receptor (K_i = 45 nM), although the significance of this action in humans is unknown.^[2] 6-APB showed little other affinity at a wide selection of other sites, with some exceptions like the rodent trace amine-associated receptor 1 (TAAR1).^[2][7]

The potent agonism of the serotonin 5-HT_2B receptor makes it likely that 6-APB would be cardiotoxic with chronic or long-term use, as seen with other serotonin 5-HT_2B receptor agonists such as the withdrawn serotonergic anorectic fenfluramine.^[2][12]

The pharmacokinetics of 6-APB have not been studied, however, some information can be extracted from user reports.^[4] These suggest a slow onset of 40 to 120 minutes.^[4] The drugs peak effects last 7 hours, followed by a comedown phase of approximately 2 hours, and after effects for up to 24 hours.^[4]

Although limited literature is available, there is some data on metabolism of 6-APB in rats. Its Phase I metabolism involves hydroxylation of the furan ring, then cleavage of the ring, followed by a reduction of the unsaturated aldehyde from the previous step. The resulting aldehyde may then take two paths. It is either oxidized to a carboxylic acid or reduced to an alcohol, and then hydroxylated. Phase II metabolism consists of glucuronidation. The most prevalent metabolites in rats were 3-carboxymethyl-4-hydroxyamphetamine and 4-carboxymethyl-3-hydroxyamphetamine.^[13]

6-APB, also known as 6-(2-aminopropyl)benzofuran, is a phenethylamine, amphetamine, and benzofuran and an analogue of 3,4-methylenedioxyamphetamine (MDA).

The chemical synthesis of 6-APB has been described.^[6] The synthesis by Briner and colleagues^[6] entailed refluxing 3-bromophenol with bromoacetaldehyde diethylacetal and sodium hydride to give the diethyl acetal, which then was heated with polyphosphoric acid to give a mixture of bromobenzofuran structural isomers: 4-bromo-1-benzofuran and 6-bromo-1-benzofuran. The isomers were separated by silica gel column chromatography, then converted to their respective propanone derivatives, and then reductively aminated to give 6-APB and 4-APB, both of which were converted to their HCl ion pairs for further examination.

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6-APB Benzofury CAS # 286834-85-3 or 6-(2-aminopropyl)benzofuran or 1-benzofuran-6-ylpropan-2-amine (6-APB), also known as Benzofury, is an entactogenic compound of the phenethylamine and amphetamine classes. It is a recreational drug that is similar in structure to MDA, but differs in that the 3,4-methylenedioxyphenyl ring system has been replaced with a benzofuran ring. 6-APB is also the unsaturated benzofuran derivative of 6-APDB. While the drug never became particularly popular, it briefly entered the rave and underground clubbing scene in United Kingdom before its sale and import were banned.

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Chemical Components and Synonyms

6-APB:
IUPAC Name: 1-(benzofuran-6-yl)-2-propan-2-ylaminoethanone
Common Synonyms: 6-(2-Aminopropyl)benzofuran, Benzo Fury

CAS Number

6-APB: 286834-85-3

Molecular Formula and Structure

6-APB:
Molecular Formula: C11H13NO
Structural Diagram:

   O
  //
 ||   ||
   //
    |
  H2C-CH(NH2)-CH3

Purity and Grade

Purity: ≥ 98%
Grade: Research Grade

Physical and Chemical Properties

• Form: Capsules
• Dose per Capsule: 100mg
• Melting Point: Not readily available
• Boiling Point: Not typically applicable for solid research chemicals
• Solubility: Soluble in organic solvents like ethanol and DMSO
• Density: Not readily available
• Molecular Weight: Approximately 175.23 g/mol

Safety and Handling Information

• Hazard Symbols: ⚠️ 💀
• Precautionary Statements:
  • Avoid inhalation, ingestion, and contact with skin and eyes.
  • Use personal protective equipment (PPE) such as gloves and safety goggles.
• First-Aid Measures:
  • If inhaled, move to fresh air and seek medical attention.
  • In case of skin contact, rinse with plenty of water and soap.
  • If ingested, do not induce vomiting; seek immediate medical help.

Usage and Applications

6-APB Capsules are primarily used in pharmacological research to investigate the effects of 6-APB. Studies may focus on its psychoactive properties and potential interactions with neurotransmitter systems, offering a high-purity form for precise research applications.

Storage Conditions

Store in a cool, dry place away from direct sunlight. Keep the container tightly closed and store at temperatures between 2-8°C.

Regulatory Information

This product complies with international chemical safety standards, including REACH and GHS classification.

Shipping Information

Clients are responsible for verifying the legal status of 6-APB in their country before purchasing. Our packaging meets industry standards to ensure safe delivery, and we offer various shipping options for your convenience.

Technical Support and Contact Information

For any questions or technical support, please visit our Contact Us page.

FAQ

1. What is the form of 6-APB in this product?

6-APB is provided in capsule form, with each capsule containing 100mg of high-purity 6-APB.

2. What are the typical applications of 6-APB Capsules?

They are used in pharmacological research to study the psychoactive properties and potential interactions with neurotransmitter systems.

3. How should I store 6-APB Capsules?

Store them in a cool, dry place away from direct sunlight, at temperatures between 2-8°C.

4. Are there any shipping restrictions for 6-APB Capsules?

Yes, clients must verify the legal status of 6-APB in their country before purchasing.

5. Who do I contact if I have questions about 6-APB Capsules?

For any inquiries, please visit our Contact Us page for assistance.

6-APB Powder is a high-purity research chemical belonging to the aminoalkylbenzofuran class. It acts as a serotonin–norepinephrine–dopamine releasing agent and reuptake inhibitor, making it valuable for neuropharmacological research focused on monoamine neurotransmitter systems. This white crystalline powder is intended strictly for laboratory research and scientific studies.

Chemical Structure / Physical Properties

• Chemical Name: 6-(2-Aminopropyl)benzofuran (6-APB)

• Purity: ≥99%

• Form: Powder

• Color/Appearance: White crystalline powder

• CAS Number: 286834-85-3

Intended Use

For research purposes only. 6-APB is used to study stimulant and entactogenic effects, serotonin receptor agonism, and monoamine transporter interactions. Not intended for human consumption.

Packaging & Shipping

Orders are shipped discreetly with tracking provided. USA shipments typically arrive within 24-72 hours; international deliveries may take up to 5 days depending on location. Packaging ensures product stability and confidentiality.

Legal & Compliance Disclaimer

This product is sold strictly for research use and is not for human consumption. Customers must verify the legal status of 6-APB in their jurisdiction before ordering. Purchasers must be 18 years or older. We reserve the right to accept or decline orders based on intended use.

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