Buy Methoxphenidine (MXP 2-MXP) Cas 2055777-48-3
Buy Methoxphenidine (MXP 2-MXP) Cas 2055777-48-3
Methoxphenidine (also known as 2-MXP or MXP) is a lesser-known novel dissociative substance of the diarylethylamine class. It is an NMDA antagonist with subjective effects similar to those of ketamine and phencyclidine (PCP). It is structurally related to diphenidine and ephenidine.[1]
Methoxphenidine has been studied alongside other diarylethylamines as a treatment for neurotoxic injuries.[2][3][4][5][6] The first reports of human recreational use appeared shortly after the 2013 U.K. arylcyclohexylamine ban, during which it and diphenidine began to be sold in powder and tablet form on the online research chemical market.[7] It was initially marketed by vendors as a replacement for the highly popular methoxetamine (MXE) despite little to no evidence that it possessed similar effects.
Subjective effects include depersonalization, disconnective effects, conceptual thinking, increased music appreciation, and euphoria. Methoxphenidine belongs to a class of substances that can induce a hallucinogenic state known as “dissociative anesthesia”, in which the user feels detached from their bodies.
Very little data exists about the pharmacological properties, metabolism, and toxicity of methoxphenidine and it has an extremely limited history of human usage. A number of fatal and non-fatal overdoses have been linked to the abuse of diarylethylamines.[1] Additionally, a number of user reports suggest that they may carry different and more pronounced risks than traditional dissociatives.
It is highly advised to use harm reduction practices if using this substance. Buy Methoxphenidine (MXP 2-MXP) Cas 2055777-48-3
History and culture
Methoxphenidine is an example of a designer drug, specifically chosen to mimic the functional or structural features of commonly used illicit substances and circumvent government regulation.[8][9]
Chemistry
Methoxphenidine, or 2-MeO-Diphenidine, is a synthetic compound of the diarylethylamine class. Methoxphenidine’s chemical structure contains a substituted phenethylamine skeleton with an additional phenyl ring bound to Rα. The terminal amino group of the phenethylamine chain is incorporated into a piperidine ring. Hence, methoxphenidine belongs to the piperidine dissociative class of compounds.
Methoxphenidine is a structural analog of diphenidine, featuring a methoxy group at the two position of a phenyl group. Buy Methoxphenidine (MXP 2-MXP) Cas 2055777-48-3Buy Methoxphenidine (MXP 2-MXP) Cas 2055777-48-3
Pharmacology
MXP acts as an NMDA receptor antagonist.[10] NMDA receptors allow for electrical signals to pass between neurons in the brain and spinal column; for the signals to pass, the receptor must be open. Dissociatives close the NMDA receptors by blocking them. This disconnection of neurons leads to loss of feeling, difficulty moving, and eventually an almost identical equivalent of the “k-hole.”
Although it has not been formally studied, the feelings of physical and emotional euphoria which many users report suggests that it may also have action as a dopamine and / or a noradrenaline reuptake inhibitor.
Subjective effects
It should be noted that like other diaryethylamines, methoxphenidine is reported to have a much more rapid onset and lower half-life when vaporized or smoked. When consumed this way, it is a suspected to be carcinogenic when excess heat is used. Some user reports have concluded that vaporization requires as low as 20% of what would be a common oral dose for that person.
Disclaimer: The effects listed below cite the Subjective Effect Index (SEI), an open research literature based on anecdotal user reports and the personal analyses of PsychonautWiki contributors. As a result, they should be viewed with a healthy degree of skepticism.
It is also worth noting that these effects will not necessarily occur in a predictable or reliable manner, although higher doses are more liable to induce the full spectrum of effects. Likewise, adverse effects become increasingly likely with higher doses and may include addiction, severe injury, or death ☠. Buy Methoxphenidine (MXP 2-MXP) Cas 2055777-48-3
Physical effects
- The physical effects of MXP are most similar to that of DXM than other commonly used dissociatives. They can be broken down into several components which progressively intensify proportional to dosage. These are described below and generally include:
- Tactile disconnection – This results in typical states of progressive physical disconnection but is far more consciously controllable than that of other dissociatives. This allows one to choose how much of their body they are currently aware of and connected to simply by directing their focus towards it even throughout higher states of disconnection and out-of-body experiences.
- Pain relief
- Spontaneous physical sensations – The MXP “body high” is a soft, pleasurable vibrating sensation which can be felt all over the body which progressively intensifies throughout the onset before dissipating once the peak has been reached.
- Tactile suppression – This partially to entirely suppresses one’s own sense of touch, creating feelings of numbness within the extremities. It is responsible for the anaesthetic properties of this substance.
- Motor control loss – A loss of gross and fine motor control alongside of balance and coordination is prevalent within MXP and becomes especially strong at higher dosages. This means that one should be sitting down before the onset unless they are experienced in case of falling over and injuring oneself.
- Euphoria – This results in feelings of physical euphoria which range between mild pleasure to powerfully all-encompassing bliss. Buy Methoxphenidine (MXP 2-MXP) Cas 2055777-48-3
- Perception of bodily lightness – This creates the sensation that the body is floating and has become entirely weightless. This effect is strangely stimulating and encourages physical activities at low to moderate dosages by making the body feel light and effortless to move.
- Dizziness – Although uncommon, some people report dizziness under the influence of MXP.
- Physical autonomy
- Spatial disorientation
- Orgasm suppression
- Gait alteration
Visual effects
-
Suppression
- Visual disconnection – This eventually results in MXP’s equivalent of the famous “K-hole” or more specifically, holes, spaces and voids alongside of structures.
- Visual acuity suppression
- Double vision – This component is prevalent at moderate to heavy dosages and makes reading impossible unless one closes an eye. Buy Methoxphenidine (MXP 2-MXP) Cas 2055777-48-3
- Pattern recognition suppression – This effect generally occurs at higher dosages and makes one unable to recognize and interpret perceivable visual data.
- Frame rate suppression
Distortions
Geometry
Hallucinatory states
At high dosages, MXP can produce a full range of high level hallucinatory states in a fashion that is less consistent and reproducible than that of many other commonly used psychedelics. These effects include: Buy Methoxphenidine (MXP 2-MXP) Cas 2055777-48-3
- Internal hallucination (autonomous entities; settings, sceneries, and landscapes; perspective hallucinations and scenarios and plots) – In comparison to other dissociatives, this effect can occur at heavy dosages, but is considerably less common than the same effect found within psychedelics and deliriants. It feels very dream-like and can be comprehensively described through its variations as delirious in believability, fixed in style, equal in new experiences and memory replays in content, extremely controllable in content and solid in style. Buy Methoxphenidine (MXP 2-MXP) Cas 2055777-48-3
Cognitive effects
- The cognitive effects of MXP are often described as particularly clear-headed in comparison to other dissociatives even at heavy dosages. It is far more controllable, less disorientating and confusing at dosages of equal subjective intensity to that of MXE, DXM and ketamine. The cognitive effects of MXP can be broken down into several separate subcomponents which are listed and described below:
- Depersonalization
- Derealization
- Dream potentiation
- Consciousness disconnection
- Thought acceleration
- Memory suppression
- Thought deceleration
- Increased music appreciation
- Analysis suppression
- Time distortion – Feelings of time dilation and more time having passed than it actually has are common at moderate to strong dosages.
- Euphoria
- Conceptual thinking
- Anxiety suppression
- Disinhibition
- Amnesia
Auditory effects
-
- Suppression
- Distortions – The auditory distortion which is present at moderate to high doses of MXP can be described as a concomitant, audial component of frame rate suppression. This causes one to hear sound at a lagged frame rate. This can be described as 2 -15 seconds longer, with repeating, extremely distorted syllables at heavy dosages.
- Hallucinations – Audial time dilation experienced at moderate to heavy dosages can be described as being processed 2-5 seconds after occurring, having an extremely low frame rate with echoing, lengthy syllables. Buy Methoxphenidine (MXP 2-MXP) Cas 2055777-48-3
After effects
- The afterglow describes the effects that can occur within 24 hours after the experience. Many users report the afterglow to be as long-lasting and desirable as the experience itself. It can be described in terms of its physical sensation as one of euphoria, rejuvenation, relaxation and a bodily lightness. In terms of its mental thought processes, it can be described as a significant reduction or loss of anxiety, feelings of contentedness and a highly increased appreciation for music which dissipates a day or so after the experience.
Experience reports
Anecdotal reports which describe the effects of this compound within our experience index include:
Additional experience reports can be found here:
MXP
MXP is a substance sold only for research purposes and is therefore not intended for consumption.
MXP retains its stability for up to 2 years when stored in the proper environment. MXP is intended for research purposes and not for consumption. Therefore, it is important to keep the product out of the reach of children and pets.4-HO-MET Fumarate
We offer good quality research chemicals at a fair price. Your order will be shipped every day within 24 hours. Please order MXP safely and quickly via !3-MEC
MXP features
Synonym: Methoxphenidine, Methoxyphenidine, MXP, 2-MXP
CAS Number: 127529-46-8
Formula: C20H25NO
Molmass: 295.426 g/mol
Purity: >97%
Diphenidine is a homeomorph of MK-801, which like arylcyclohexylamines, can act as an NMDA receptor channel blocker, resulting in neuroprotective and dissociative effects. [1] Methoxphenidine is an analog of diphenidine featuring a methoxy group at the two position of a phenyl group. The physiological and toxicological properties of this compound are not known. This product is intended for forensic and research applications.
Reference:
[1]. Berger, M.L., Schweifer, A., Rebernik, P., et al. NMDA receptor affinities of 1,2-diphenylethylamine and 1-(1,2-diphenylethyl)piperidine enantiomers and of related compounds. Bioorg. Med. Chem. 17(9), 3456-3462 (2009).
| Cas No. | 2055777-48-3 | SDF | |
| Synonyms | 2-MeO-Diphenidine | ||
| Chemical Name | 1-(1-(2-methoxyphenyl)-2-phenylethyl)piperidine, monohydrochloride | ||
| Canonical SMILES | COC1=CC=CC=C1C(N2CCCCC2)CC3=CC=CC=C3.Cl | ||
| Formula | C20H25NO•HCl | M.Wt | 331.9 |
| Solubility | 30mg/mL in DMSO, 50mg/mL in DMF, 30mg/mL in Ethanol | Storage | Store at -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
||
| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 3.013 mL | 15.0648 mL | 30.1296 mL |
| 5 mM | 602.6 μL | 3.013 mL | 6.0259 mL |
| 10 mM | 301.3 μL | 1.5065 mL | 3.013 mL |
Hazard designation
MXP may cause respiratory irritation
MXP can cause irritation in the eyes.
Research chemicals discharge into the environment is prohibited.
MXP IN CONTACT WITH EYES: Rinse eyes carefully with water for five minutes. Remove contact lenses if possible.
MXP IN CONTACT WITH SKIN: wash skin with soap and water.2C-E
AFTER INHALING MXP: Move the victim into fresh air and have the victim in a position that makes breathing easy. Buy Methoxphenidine (MXP 2-MXP) Cas 2055777-48-3
Toxicity and harm potential
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- Cayman Chemical Forensics: Supplies methoxphenidine hydrochloride for authorized research use; requires a valid UK Home Office license or equivalent local regulatory permits.
- LGC Standards: Provides verified reference solutions and standards for chemical analysis.
- Benchchem: Offers methoxphenidine and related analogs for research and development laboratories. [1]
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Methoxphenidine – Wikipedia
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National Institutes of Health
Methoxphenidine hydrochloride (CAS 127529-46-8)
Methoxphenidine
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