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Phencyclidine or phenylcyclohexyl piperidine (PCP), also known in its use as a street drug as angel dust among other names, is a dissociative anesthetic mainly used recreationally for its significant mind-altering effects.[1][4] PCP may cause hallucinations, distorted perceptions of sounds, and psychotic behavior.[4][7][8] As a recreational drug, it is typically smoked, but may be taken by mouth, snorted, or injected.[4][5][7] It may also be mixed with cannabis or tobacco.[1][4]
Adverse effects may include paranoia, addiction, and an increased risk of suicide, as well as seizures and coma in cases of overdose.[7] Flashbacks may occur despite stopping usage.[8] Chemically, PCP is a member of the arylcyclohexylamine class.[4][9][10] PCP works primarily as an NMDA receptor antagonist.[9]
PCP is most commonly used in the US.[11] While usage peaked in the US in the 1970s,[12] between 2005 and 2011, an increase in visits to emergency departments as a result of the drug occurred.[7] As of 2022, in the US, about 0.7% of 12th-grade students reported using PCP in the prior year, while 1.7% of people in the US over age 25 reported using it at some point in their lives. Buy Phencyclidine (PCP) Cas-77-10-1
Recreational uses
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Phencyclidine is used for its ability to induce a dissociative state.[14]
Effects
Behavioral effects can vary by dosage. Low doses produce numbness in the extremities and intoxication, characterized by staggering, unsteady gait, slurred speech, bloodshot eyes, and loss of balance. Moderate doses (5–10 mg intranasal, or 0.01–0.02 mg/kg intramuscular or intravenous) will produce analgesia and anesthesia. High doses may lead to convulsions.[15] The drug is often illegally produced under poorly controlled conditions; this means that users may be unaware of the actual dose they are taking.[16]
Psychological effects include severe changes in body image, loss of ego boundaries, paranoia, and depersonalization. Psychosis, agitation and dysphoria, hallucinations, blurred vision, euphoria, and suicidal impulses are also reported, as well as occasional aggressive behavior.[17][18]: 48–49 [15] PCP may induce feelings of strength, power, and invulnerability as well as a numbing effect on the mind.[5]
Studies by the Drug Abuse Warning Network in the 1970s show that media reports of PCP-induced violence are greatly exaggerated and that incidents of violence are unusual and often limited to individuals with reputations for aggression regardless of drug use.[18]: 48 Although uncommon, events of PCP-intoxicated individuals acting in an unpredictable fashion, possibly driven by their delusions or hallucinations, have been publicized.[19] Other commonly cited types of incidents include inflicting property damage and self-mutilation of various types, such as pulling out one’s teeth.[18]: 48 [19] These effects were not noted in its medicinal use in the 1950s and 1960s, however, reports of physical violence on PCP have often been shown to be unfounded.[20][21]
Recreational doses of the drug also occasionally appear to induce a psychotic state, with emotional and cognitive impairment that resembles a schizophrenic episode.[22][23] Users generally report feeling detached from reality.[24]
Symptoms are summarized by the mnemonic device RED DANES: rage, erythema (redness of skin), dilated pupils, delusions, amnesia, nystagmus (oscillation of the eyeball when moving laterally), excitation, and skin dryness.[25]
Addiction
PCP is self-administered and induces ΔFosB expression in the D1-type medium spiny neurons of the nucleus accumbens,[3][26] and accordingly, excessive PCP use is known to cause addiction.[3] PCP’s rewarding and reinforcing effects are at least partly mediated by blocking the NMDA receptors in the glutamatergic inputs to D1-type medium spiny neurons in the nucleus accumbens.[3] PCP has been shown to produce conditioned place aversion and conditioned place preference in animal studies.[27]
Schizophrenia
A 2019 review found that the transition rate from a diagnosis of hallucinogen-induced psychosis (which included PCP) to that of schizophrenia was 26%. This was lower than cannabis-induced psychosis (34%) but higher than amphetamine– (22%), opioid– (12%), alcohol– (10%), and sedative-induced (9%) psychoses. In comparison, the transition rate to schizophrenia for “brief, atypical and not otherwise specified” psychosis was found to be 36%.[28]
Methods of administration
PCP has multiple routes of administration. Most commonly, the powder form of the drug is snorted. PCP can also be orally ingested, injected subcutaneously or intravenously, or smoked laced with marijuana or cigarettes.[29]
- PCP can be ingested through smoking. “Fry” and “sherm” are street terms for marijuana or tobacco cigarettes that are dipped in PCP and then dried.[30]
- PCP hydrochloride can be insufflated (snorted), depending upon the purity. This is most often referred to as “angel dust”.[29]
- An oral pill can also be compressed from the co-compounded powder form of the drug. This is usually referred to as “peace pill”.[29]
- The free base is hydrophobic and may be absorbed through skin and mucous membranes (often inadvertently). This form of the drug is commonly called “wack”.[29]
Management of intoxication
Management of PCP intoxication mostly consists of supportive care – controlling breathing, circulation, and body temperature – and, in the early stages, treating psychiatric symptoms.[31][32][33] Benzodiazepines, such as lorazepam, are the drugs of choice to control agitation and seizures (when present). Typical antipsychotics such as phenothiazines and haloperidol have been used to control psychotic symptoms, but may produce many undesirable side effects – such as dystonia – and their use is therefore no longer preferred; phenothiazines are particularly risky, as they may lower the seizure threshold, worsen hyperthermia, and boost the anticholinergic effects of PCP.[31][32] If an antipsychotic is given, intramuscular haloperidol has been recommended.[33][34][35]
Forced acid diuresis (with ammonium chloride or, more safely, ascorbic acid) may increase the clearance of PCP from the body, and was somewhat controversially recommended in the past as a decontamination measure.[31][32][33] However, it is now known that only around 10% of a dose of PCP is removed by the kidneys, which would make increased urinary clearance of little consequence; furthermore, urinary acidification is dangerous, as it may induce acidosis and worsen rhabdomyolysis (muscle breakdown), a not-unusual manifestation of PCP toxicity.[31][32]
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ChemistryMF: C17H25N HistoryPhencylidine (77-10-1) was first synthesized in 1926, and later tested after World War II as a surgical anesthetic. Because of its adverse side effects, such as hallucinations, mania, delirium, and disorientation, it was shelved until the 1950s. In 1953, it was patented by Parke-Davis and named Sernyl (referring to serenity), but was withdrawn from the market two years later because of side-effects. It was renamed Sernylan in 1967, and marketed as a veterinary anesthetic, but again discontinued. Its side effects and long half-life in the human body made it unsuitable for medical applications. Toxicity Data With Reference
Safety ProfilePoison by intraperitoneal route. Experimental reproductive effects. Caution: This is a controlled substance (depressant) listed in the U.S. Code of Federal Regulations, Title 21 Part 1308.12 (1985). The ethylamine, pyrrolidine and thiophene analogs are listed as hallucinogens, Title 21 Part 1308.11. When heated to decomposition it emits toxic fumes of NOx. SpecificationPhencyclidine (77-10-1)(a complex clip of the chemical name phenylcyclohexylpiperidine, commonly initialised as PCP), also known as angel dust and other street names, is a recreational, dissociative drug formerly used as an anaesthetic agent, exhibiting hallucinogenic and neurotoxic effects. Developed in 1926, it was first patented in 1952 by the Parke-Davis pharmaceutical company and marketed under the brand name Sernyl. In chemical structure, PCP is an arylcyclohexylamine derivative, and, in pharmacology, it is a member of the family of dissociative anesthetics. PCP works primarily as an NMDA receptor antagonist, which blocks the activity of the NMDA receptor. Other NMDA receptor antagonists include ketamine, tiletamine, and dextromethorphan. Although the primary psychoactive effects of the drug lasts for a few hours, the total elimination rate from the body typically extends 8 days or longer. Liquid PCP (Phencyclidine)$135.00 – $2,500.00 Liquid PCP (Phencyclidine) is a high-purity research chemical supplied at 99% purity for advanced scientific studies. It is a colorless, odorless liquid, soluble in water, and stable under recommended conditions. Our product is shipped worldwide with discreet, vacuum-sealed packaging to ensure confidentiality and product integrity. Physical and Chemical Properties:
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