Buy Phenazocine (Prinadol) Cas 58073-76-0

Buy Phenazocine (Prinadol) Cas 58073-76-0

Phenazocine (brand names Prinadol, Narphen) is an opioid analgesic drug, which is related to pentazocine and has a similar profile of effects.^[2]

Effects of phenazocine include analgesia and euphoria, also may include dysphoria and hallucinations at high doses, most likely due to action at κ-opioid and σ receptors.^[3] Phenazocine appears to be a much stronger analgesic with fewer side effects than pentazocine, probably due to a more favorable μ/κ binding ratio. Phenazocine is a much more potent analgesic than pentazocine and other drugs in the benzomorphan series, most probably due to the presence of an N-phenethyl substitution, which is known to boost μ-opioid activity in many classes of opioid analgesics.^[4] Also, it does not cause spasm of the sphincter of Oddi, making it more suitable than morphine for the treatment of biliary or pancreatic pain. Buy Phenazocine (Prinadol) Cas 58073-76-0

Regarding the two enantiomers of phenazocine, (R)-phenazocine^{[clarification needed]} has twenty times the potency of morphine as an analgesic,^[6] while (S)-phenazocine has about four times the potency of morphine.^{[7][full citation needed] Buy Phenazocine (Prinadol) Cas 58073-76-0}

Phenazocine was invented in the 1950s.^[8][9] It was one of a number of benzomorphan opioids (including pentazocine, dezocine, and cyclazocine) developed in the search for non-addictive strong analgesics. Buy Phenazocine (Prinadol) Cas 58073-76-0

Phenazocine was once widely used, and was mainly supplied as 5 mg tablets of the hydrobromide salt for sublingual use (Narphen, Prinadol and other names), but its use was discontinued in the United Kingdom in 2001.^{[10] Buy Phenazocine (Prinadol) Cas 58073-76-0}

Phenazocine was briefly used in the United States but fell out of favor;^{[citation needed]} it remains a Schedule II substance under the Comprehensive Drug Abuse Control & Prevention Act (Controlled Substances Act) of 1970 (CSA) but is not manufactured. The DEA ACSCN for phenazocine is 9715 and its 2013 annual manufacturing quota was 6 grams Buy Phenazocine (Prinadol) Cas 58073-76-0, Buy Phenazocine (Prinadol) Cas 58073-76-0, Buy Phenazocine (Prinadol) Cas 58073-76-0, Buy Phenazocine (Prinadol) Cas 58073-76-0, Buy Phenazocine (Prinadol) Cas 58073-76-0, Buy Phenazocine (Prinadol) Cas 58073-76-0, Buy Phenazocine (Prinadol) Cas 58073-76-0, Buy Phenazocine (Prinadol) Cas 58073-76-0, Buy Phenazocine (Prinadol) Cas 58073-76-0, Buy Phenazocine (Prinadol) Cas 58073-76-0, Buy Phenazocine (Prinadol) Cas 58073-76-0, Buy Phenazocine (Prinadol) Cas 58073-76-0

(-)-Phenazocine

Base Information

• Chemical Name:(-)-Phenazocine
• CAS No.:58640-87-2
• Molecular Formula:C₂₂H₂₇NO
• Molecular Weight:321.462
• Hs Code.:

Synonyms:(-)-Phenazocine

 This product is a nationally controlled contraband, and the Lookchem platform doesn’t provide relevant sales information.

Technology Process of (-)-Phenazocine

There total 4 articles about (-)-Phenazocine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

108-24-7acetic anhydride

127-35-5,56942-74-6,58073-76-0,58640-87-2,64023-93-4,100100-58-1(+/-)-6,11syn-dimethyl-3-phenethyl-1,2,3,4,5,6-hexahydro-2,6-methano-benz[d]azocin-8-ol

Guidance literature:

Erwaermen des Reaktionsprodukts mit Bromcyan in Chloroform,Erhitzen Rueckstandes mit wss.Salzsaeure, Behandeln mit wss.Methanol, Kaliumcarbonat und Phenylacetylchlorid und Erwaermen mit LiAlH₄;

DOI:10.1021/jo01092a012

Reference yield:

108-24-7acetic anhydride

3734-52-9,21286-57-7,21286-60-2,25144-79-0,25145-09-9,58640-79-2,64023-94-5,67009-58-9,69831-04-5,36402-80-9,75257-89-5,1509-00-8(+)-3,6,11syn-trimethyl-1,2,3,4,5,6-hexahydro-2,6-methano-benz[d]azocin-8-ol

127-35-5,56942-74-6,58073-76-0,58640-87-2,64023-93-4,100100-58-1(+)-6,11syn-dimethyl-3-phenethyl-1,2,3,4,5,6-hexahydro-2,6-methano-benz[d]azocin-8-ol

Guidance literature:

Erwaermen des Reaktionsprodukts mit Bromcyan CHCl₃, Erhitzen mit wss.Salzsaeure, Behandeln mit wss.Methanol, Kaliumcarbonat und Phenylacetylchlorid und Erwaermen mit LiAlH₄;

DOI:10.1021/jo01092a012

Reference yield:

Phenazocine is much more potent as an analgesic than pentazocine and other drugs in the benzomorphan series, most probably due to the presence of an N-phenethyl substitution, which is known to boost μ-opioid activity in many classes of opioid analgesics.^[4] Consequently phenazocine is some 4x the potency of morphine as an analgesic. Also it does not cause spasm of the sphincter of Oddi, making it more suitable than morphine for the treatment of biliary or pancreatic pain.^[5]

References

1. ^ Clarke EGC. Identification of Phenazocine, a Potent New Analgesic. Nature. 1959; 184: 451.
2. ^ Eckenhoff JE. Phenazocine, a new benzomorphan narcotic analgesic. Anesthesiology. 1959 May-Jun;20(3):355-8.
3. ^ Harris LS, Pierson AK. Some Narcotic Antagonists in the Benzomorphan Series. Journal of Pharmacology and Experimental Therapeutics. 1964 Feb;143:141-8.
4. ^ Feinberg AP, Creese I, Snyder SH. The opiate receptor: a model explaining structure-activity relationships of opiate agonists and antagonists. Proceedings of the National Academy of Sciences U S A. 1976 Nov;73(11):4215-9.
5. ^ Hopton D. Double-blind clinical trial of the analgesic effects of phenazocine hydrobromide (Narphen) compared with morphine sulphate in patients with acute abdominal pain. Gut. 1971 Jan;12(1):51-4.

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Category: Opioids

108-24-7acetic anhydride

127-35-5,56942-74-6,58073-76-0,58640-87-2,64023-93-4,100100-58-1(-)-6,11syn-dimethyl-3-phenethyl-1,2,3,4,5,6-hexahydro-2,6-methano-benz[d]azocin-8-ol

Guidance literature:

Erwaermen des Reaktionsprodukts mit Bromcyan in Chloroform, Erhitzen Rueckstandes mit wss.Salzsaeure, Behandeln mit wss.Methanol, Kaliumcarbonat und Phenylacetalchlorid und Erwaermen mit LiAlH₄;

DOI:10.1021/jo01092a012

1. Phenazocine | C22H27NO | CID 14707 – PubChem

   PHENAZOCINE is a small molecule drug with a maximum clinical trial phase of II and is indicated for pain.

   • Phenazocine, (-) C22h27no | CID 443405

     Phenazocine, (-)- | C22H27NO | CID 443405 – structure, chemical names, physical and chemical properties, classification, patents, literature, biological a…

2. Phenazocine – Wikipedia

   Phenazocine was invented in the 1950s. It was one of a number of benzomorphan opioids (including pentazocine, dezocine, and cyclazocine) developed in the search for non-addictive strong analgesics.
   Phenazocine was once widely used, and was mainly supplied as 5 mg tablets of the hydrobromide salt for sublingual use (Narphen, Prinadol and other names), but its use was discontinued in the United Kingdom in 2001.

   Wikipedia · Text under CC-BY-SA license

3. 2,6-Methano-3-benzazocin-8-ol, 1,2,3,4,5,6-hexahydro-6,11-dimethyl …

   2,6-Methano-3-benzazocin-8-ol, 1,2,3,4,5,6-hexahydro-6,11-dimethyl-3- (2-phenylethyl)-, (2R,6R,11R)-rel- (CAS 58073-76-0) information, including chemical properties, structure, melting point, boiling …

4. Phenazocine – LookChem

   Base Information Edit Chemical Name:(-)-Phenazocine CAS No.: 58640-87-2 Molecular Formula:C22H27NO Molecular Weight:321.462

5. Phenazocine – chemeurope.com

   Phenazocine used to be widely used in medicine, mainly supplied as 5mg tablets of the hydrobromide salt, but was discontinued in 2001 and is now no longer used. [1]

   • CAS number: 127-35-5
   • Mol. mass: 321.46 g/mol

   • Formula: C22H27NO
   • PubChem: 14707
6. phenazocine – ChemBK

   Phenazocine is an opioid analgesics drug related to pentacine (P274300) and has a similar profile of effects. The use of Phenazocine results in analgesia and euphoria and in some cases dysphoria and …

7. NCATS Inxight Drugs — PHENAZOCINE

   Description (-)-Phenazocine is an opioid analgesic drug, which is related to pentazocine and has a similar profile of effects. (-)-Phenazocine is a potent mu opioid receptor agonist. In addition, (−) …

8. Prinadol generic. Price of prinadol. Uses, Dosage, Side effects

   Prinadol drug information: uses, indications, side effects, dosage. Compare prices for generic prinadol substitutes: Narphen, Phenazocine

9. About: Phenazocine – DBpedia Association

   Phenazocine (brand names Prinadol, Narphen) is an opioid analgesic drug, which is related to pentazocine and has a similar profile of effects.

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