Buy 2-FDCK 2-Fluorodeschloroketamine 2-Fl-2-Oxo-PCM
Buy 2-FDCK 2-Fluorodeschloroketamine 2-Fl-2-Oxo-PCM
2-Fluorodeschloroketamine (also known as 2′-Fl-2-Oxo-PCM, fluoroketamine, and 2-FDCK) is a dissociative anesthetic[1] related to ketamine. Its sale and use as a designer drug has been reported in various countries.[2][3][4] It is an analogue of ketamine where the chlorine group has been replaced by fluorine. Due to its recent emergence, the pharmacological specifics of the compound are mostly unclear, but effects are reported to be similar to its parent compound, ketamine.
The N-methyl-D-aspartate receptor (NMDA-R) subunit GluN2B is abundantly expressed in brain regions critical for synaptic plasticity and cognitive processes. This study investigated the structure-activity relationships (SAR) of NMDA-R ligands using GluN2B as a molecular target. Thirty potential NMDA-R antagonists were categorized into two structural classes: 1-(1-phenylcyclohexyl) amines (series A) and α-amino-2-phenylcyclohexanone derivatives (series B). In series A compounds, the phenyl ring and R1 substituents were positioned at the carbon center of the cyclohexyl ring, with R2 substituents at the para- or meta-positions of the phenyl ring. SAR analysis reveale
2-Fluorodeschloroketamine
2-Fluorodeschloroketamine (also known as 2-Fl-2′-Oxo-PCM, Fluoroketamine and 2-FDCK) is a dissociative anesthetic. It is an analogue of ketamine where the chlorine group has been replaced by fluorine.
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| Formula | C13H16FNO |
| Molar mass | 221.275 g·mol−1 |
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Legal status
2-Fluorodeschloroketamine is illegal in Latvia, and is covered by blanket bans in Canada and the UK.
References
- Abolghasem Moghimi; Siyavash Rahmania; Reza Zare; Morteza Sadeghzadeh (2014). “Synthesis of 2-(2-Fluorophenyl)-2-methylamino-Cyclohexanone as a New Ketamine Derivative”. Synthetic Communications. 44 (14): 2021–2028. doi:10.1080/00397911.2014.885053.
- Noteikumi par Latvijā kontrolējamajām narkotiskajām vielām, psihotropajām vielām un prekursoriem
- Synonyms
- 2-(2-fluorophenyl)-2-(methylamino)-cyclohexanone, monohydrochloride
- Correlated keywords
- 111982-50-4 fluorodeschloroketamine 2FK 2-FK 2FDCK fluoroketamine 2-DCK 2DCK 2F-2-OXO-PCM 2F2-OXO-PCM 2F2OXO-PCM 2F2OXOPCM 2F-2-OXOPCM 2F-2OXOPCM
- Product Overview:
2-fluoro Deschloroketamine (hydrochloride) (Item No. 19786) is an analytical reference standard that is structurally categorized as an arylcyclohexylamine. The physiological and toxicological properties of this compound are not known. This product is intended for research and forensic applications.
History
The synthesis of 2-FDCK was first described in a 2013 paper as part of a larger effort to synthesize and evaluate new anesthetic drugs based on ketamine and its analogues.[1] Ketamine itself was first introduced in 1964 and was approved for clinical use in 1970. Since then it has become one of the most important and applicable general anesthetics as well as a popular recreational drug.
The use of 2-FDCK as a research chemical has been reported in various countries.[2][5][6] Many of these new psychoactive substances (NPS) appear on the drug market in order to circumvent existing drug policies. 2-FDCK was first formally notified by the EMCDDA in 2016, alongside 65 other new substances.[6] Due to its recent appearance, little research has been done on the compound so far.
In January 2023, Israeli Biotech company “Clearmind Medicine Inc.” announced the successful completion of a preclinical study examining 2-FDCK in a rat model of depression, with the compound outperforming ketamine in longevity of antidepressant effect. Buy 2-FDCK 2-Fluorodeschloroketamine 2-Fl-2-Oxo-PCM
Chemistry
BUY 2-FDCK
2-FDCK, or 2-Fluorodeschloroketamine, is a dissociative anaesthetic. 2-FDCK is a lesser-known dissociative substance of the arylcyclohexylamine class that produces dissociative, anesthetic, and hallucinogenic research results. 2-FDCK is, like ketamine, related to arylcyclohexylamines and deschloroketamine anf it is reported by researchers to produce similar results. 2-FDCK is not as heavily experimented with as ketamine is, however, a lot of excitement is building around 2-FDCK. When compared to synthetics such as diphenidine and methoxphenidine, 2-FDCK is probably one of the most anticipated research chemicals of all time in the dissociative class. Buy 2-FDCK 2-Fluorodeschloroketamine 2-Fl-2-Oxo-PCM
How to use 2-FDCK Powder?
2-FDCK for sale in the highest quality crystal form. Buy 2-FDCK in the quantities starting from 1gr. Ensure to store the 2-FDCK powder in a dry and cool place for maximum shelf-life. Store in a dry and cool place for maximum shelf-life. When handling research chemicals ensure to always take the proper precautions in the laboratory like wiping down surfaces and wearing gloves, a mask & protective clothing. Buy 2-FDCK 2-Fluorodeschloroketamine 2-Fl-2-Oxo-PCM
Definition 2-FDCK
The definition of 2-FDCK is officially known as 2-Fluorodeschloroketamine, 2′-Fl-2-Oxo-PCM and Fluoroketamine. It’s sometimes also known under the names 2-Fluoro Ketamine, Fluoroketamine, and 2-FK. It is a narrative of ketamine where the chlorine group has been replaced by fluorine. 2-Fluorodeschloroketamine is structurally related to arylcyclohexylamines like ketamine and deschloroketamine. Buy 2-FDCK 2-Fluorodeschloroketamine 2-Fl-2-Oxo-PCM
Chemistry background information 2-FDCK
2-FDCK was first synthesized by Mr Jack E Billau in 2019. Billau created it while investigating another Arylcyclohexylamine called Ketamine. 2-Fluorodeschloroketamine is classed as an arylcyclohexylamine. This chemical substance contains a phenyl ring bonded to a cyclohexane ring substituted with a ketone group (cyclohexanone). 2-Fluorodescholoroketamine is often used as a racemate. 2-FDCK is named for containing a fluorine substitution at its phenyl ring rather than the chlorine which is found in ketamine. Buy 2-FDCK 2-Fluorodeschloroketamine 2-Fl-2-Oxo-PCM
Due to the lack of studies and brief research history regarding the substance, all discussions of 2-FDCK are purely based on its structure and subjective effect similarities to other arylcyclohexylamine dissociatives such as DCK and ketamine. Therefore, It is strongly advised to use harm reduction practices if using this substance. Buy 2-FDCK 2-Fluorodeschloroketamine 2-Fl-2-Oxo-PCM
Where to buy 2-FDCK
2-FDCK can be purchased here on the AromaticPowders website. We sell premium quality 2-FDCK, typically in powder. However, we often have other substance forms available, so feel free to contact us to see if we have your preferred substance form in stock. You must be at least 18 years old to buy 2-FDCK from us.
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Structure
The full chemical name of 2-FDCK is 2-(2-fluorophenyl)-2-(methylamino)cyclohexan-1-one.
2-FDCK belongs to a class of compounds called arylcyclohexylamines which contains various other drugs such as PCP and ketamine. Their general structure consists of a cyclohexylamine unit with an aryl group attached to the same carbon as the amine. 2-FDCK has an o-fluorophenyl group as an aryl substituent and the amine group is methylated. The cyclohexyl ring features a ketone group next to the amine position.
The chemical structure of 2-FDCK differs from ketamine only in that there is a fluorine atom attached to the phenyl group. Ketamine has a chlorine atom in that position.[8]
Synthesis
2-FDCK can be synthesized in a five-step reaction process.[1] First 2-fluorobenzonitrile reacts with the Grignard reagent cyclopentyl magnesium bromide followed by a bromination reaction to obtain α-bromocyclopentyl-(2-fluorophenyl)-ketone. The reaction of the obtained ketone with methylamine at −40 °C then results in the formation of α-hydroxycyclopentyl-(2-fluorophenyl)-N-methylamine. Finally, the five-membered ring cyclopentanol form is expanded to a cyclohexylketone form by a thermal rearrangement reaction. HCl is used to create a water-soluble HCl salt of 2-FDCK. Buy 2-FDCK 2-Fluorodeschloroketamine 2-Fl-2-Oxo-PCM
Detection
2-FDCK and its metabolites can be detected in urine with the use of liquid chromatography mass spectrometry (LC/MS).[4][9]
Pharmacology
Metabolism
The metabolism of 2-FDCK is analogous to that of ketamine: the enzymes CYP2B6 and CYP3A4, the latter to a lesser extent, metabolise 2-FDCK to Nor-2FDCK via N-demethylation. This is further metabolised either to dehydronor-2FDCK by CYP2B6 or to hydroxynor-2FDCK by CYP2A6 and CYP2B6.[3]
In general, the 2-FDCK equivalent shows stronger docking to CYP2B6 in simulations, as well as slower metabolism rate, than the more well-known ketamine. The lipophilicity is observed to be lower for 2-FDCK than for ketamine.[3] In vitro to in vivo extrapolation predicts that in the body, 2-FDCK shows a lower intrinsic hepatic clearance than ketamine. Both of these characteristics would suggest that the effects of 2-FDCK last longer than those of ketamine.[2]
Pharmacodynamics
2-FDCK is structurally similar to ketamine, so a similar mechanism of action is expected,[10] but there has been no study done to confirm this. Due to the halogen in the 2 position not being a chlorine but a fluorine, the molecule is more polar.[3] This could influence binding to proteins, such as the NMDA receptor that ketamine primarily binds to and acts as an antagonist towards.
Comparison to other halogen-substituted ketamine variants
For general (halogen) substitutions of ketamine, docking strength for CYP2B6 follows the pattern H < Br < Cl < F. The parameter of internal clearance follows the pattern Br > Cl > F > H. Lastly, Km (Michaelis constant) follows the pattern of Br < Cl < F < H, and as such the in-vitro metabolism rate follows the inverse pattern, namely Br > Cl > F > H.[4]
Adverse effects
Possible effects and dangers
In 2019, 2-FDCK was found in poisoned individuals in Hong Kong in combination with other ketamine-type drugs.[4]
Legal status
Due to the fast emergence of NPS, new substances such as 2-FDCK are often not yet specifically mentioned in controlled substance legislation. As a result, NPS are sometimes marketed as “legal highs“. 2-FDCK is currently illegal in Italy[11] Japan,[12] Latvia,[13] Singapore,[14] Sweden,[15] Switzerland,[16] as well as being covered by blanket bans in Canada,[17] Belgium,[18] and the UK.[19]
In October 2023 the ECDD recommended that 2-FDCK be added to Schedule II of the Convention on Psychotropic Substances of 1971.[20]
As of February 2026 2F-DCK is banned in the Netherlands and not sold anymore by research chemical shops, being replaced by 2F-NENDCK.[21
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| property | value |
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| Common names | 2-Fluoroketamine, Fluoroketamine, 2-FK, 2-FDCK |
| Substitutive name | 2-Fl-2′-Oxo-PCM |
| Systematic name | (R/S)-2-(2-fluorophenyl)-2-(methylamino)cyclohexanone |
2-fl-2′-oxo-pcm (also known as 2-fluorodeschloroketamine, 2-fdck, and inaccurately as 2-fluroketamine, fluoroketamine, and 2-fk) is a lesser-known novel dissociative substance of the arylcyclohexylamine class that produces dissociative, anesthetic, and hallucinogenic effects when administered. it is structurally related to arylcyclohexylamines like ketamine and deschloroketamine and is reported to produce similar effects.
like other dissociative substances, it is primarily sought by recreational users for its ability to induce a hallucinogenic “out of body” state referred to as “dissociative anesthesia” (although the extent to which this occurs is highly dose-dependent). it has recently become available through online research chemical vendors where it is being sold as a designer drug replacement for ketamine.
there is very little information on the pharmacology, metabolism or toxicity of 2-fluorodeschloroketamine. it has an extremely brief history of human use. it is strongly advised to use harm reduction practices if using this substance.
chemistry
2-fluorodeschloroketamine, or 2-(2-fluorophenyl)-2-methylamino-cyclohexanone, is classed as an arylcyclohexylamine drug. arylcyclohexylamines drugs are named for their structures which include a cyclohexane ring bound to an aromatic ring along with an amine group. 2-fdck contains a phenyl ring bonded to a cyclohexane ring substituted with a ketone group (cyclohexanone). an amino methyl chain (-n-ch3) is bound to the adjacent alpha carbon (r2) of the cyclohexanone ring. additionally, the phenyl ring is substituted at r2 with a fluorine group.
2-fluorodescholoroketamine is a chiral molecule and is often produced as a racemate. des- is a prefix used in chemistry to denote the absence of a functional group (in this case “chloro”) hence 2-fdck is named for containing a fluorine substitution at its phenyl ring rather than the chlorine which is found in ketamine.
pharmacology
due to the lack of research regarding the substance, all discussion regarding the pharmacology of it is purely based on its structure and subjective effect similarities to other arylcyclohexylamine dissociatives such as dck and ketamine. with this in mind, 2-fluorodeschloroketamine is thought to act as an nmda receptor antagonist.
nmda receptors allow for electrical signals to pass between neurons in the brain and spinal column; for the signals to pass, the receptor must be open. dissociatives close the nmda receptors by blocking them. this disconnection of neurons leads to loss of feeling, difficulty moving, and eventually this substance’s equivalent of the “k-hole.”
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- Regulatory Status: 2-FDCK is considered a “new psychoactive substance” and is strictly monitored or explicitly classified as a controlled substance in many jurisdictions (including under the World Health Organization’s global guidelines).
- Research Restrictions: Sale is universally restricted to certified facilities and licensed professionals. It carries similar physiological risks and abuse potential as its parent compound, ketamine. [1, 2, 3, 4, 5, 6]
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2-Fluorodeschloroketamine – Wikipedia
2-Fluorodeschloroketamine (also known as 2′-Fl-2-Oxo-PCM, fluoroketamine, and 2-FDCK) is a dissociative anesthetic related to keta…
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2-Fluorodeschlorokétamine – Wikipédia
La 2-Fluorodeschlorokétamine (ou 2-FDCK, parfois fluorokétamine) est un composé organique utilisé pour ses propriétés anesthésiant…
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Critical review report: 2-Fluorodeschloroketamine Expert …
Critical review report: 2-Fluorodeschloroketamine Expert Committee on Drug Dependence Forty-sixth Meeting Geneva, 16–20 Oc. Page 1…
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2-fluoro Deschloroketamine (hydrochloride) – CAT N°: 19786
CAT N°: 19786. 2-fluoro Deschloroketamine (hydrochloride) (Item No. 19786) is an analytical reference standard that is structurall…
2-Fluorodeschloroketamine – Drug Targets, Indications, …
2-Fluorodeschloroketamine | C13H16FNO | CID 13771618
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