Buy Nandrolone decanoate Cas 360-70-3

Buy Nandrolone decanoate Cas 360-70-3

Nandrolone decanoate, sold under the brand names Rolon  and Deca-Durabolin, among others, is an androgen and anabolic steroid (AAS) medication which is used primarily in the treatment of anemias and wasting syndromes, as well as osteoporosis in menopausal women.^{[8][9][10][11][3]} It is given by injection into muscle or fat once every one to four weeks.^[3][12]

Side effects of nandrolone decanoate may include symptoms of masculinization like acne, increased hair growth, and voice changes.^[3] The medication is a synthetic androgen and anabolic steroid and hence is an agonist of the androgen receptor (AR), the biological target of androgens like testosterone and dihydrotestosterone (DHT).^[3][13] It has strong anabolic effects and weak androgenic effects, which give it a mild side effect profile and make it especially suitable for use in women and children.^[3][13][14] Nandrolone decanoate is a nandrolone ester and a long-lasting prodrug of nandrolone in the body.^[3][15]

Nandrolone decanoate was first described in 1960 and was introduced for medical use in 1962.^[3] It was the second nandrolone ester to be introduced, following nandrolone phenylpropionate (NPP) in 1959, and is one of the most widely used nandrolone esters.^[3][16] It is also one of the most widely used AAS worldwide.^[3] In addition to its medical use, nandrolone decanoate is used to improve physique and performance, and is said to be the most widely used AAS for such purposes.^[3][17] The drug is a controlled substance in many countries and so non-medical use is generally illicit.^[3]

Nandrolone decanoate is approved in the United States specifically for the treatment of anemia of chronic kidney disease and in the United Kingdom specifically for the treatment of osteoporosis in postmenopausal women.^[3][18][19] In Australia, it is approved specifically for the treatment of kidney failure, chronic kidney disease, anemia of kidney failure, aplastic anemia, osteoporosis (in women in whom estrogens are contraindicated), inoperable breast cancer, and for patients on long-term corticosteroid therapy.^[6] In New Zealand, it is approved for osteoporosis, inoperable breast cancer, and as an adjunct to therapy for conditions characterized by a negative nitrogen balance.^[2] The drug is often used off-label to preserve lean mass in HIV/AIDS patients and in other wasting syndromes.^[3]

In the past, nandrolone decanoate has also been indicated and used for a variety of other conditions and situations including pre- and postoperative use for increasing lean mass, treating weight loss due to convalescence or disease, geriatric states (e.g., general weakness, fatigue), burns, severe trauma, ulcers, and selected cases of growth failure in children.^[3] Starting in the 1970s, the indications of nandrolone decanoate were refined and use of the drug became more selective and restricted.^[3] Its use in medicine continues to decline and has become limited, with its sale having been discontinued in many countries.^[3]

Nandrolone esters can be used as a form of androgen replacement therapy for treatment of androgen deficiency in men.^[20] However, they have not generally been used for this purpose, and have instead mostly been used only as anabolic agents.^[20][21][22] In any case, nandrolone decanoate has widely been used at low doses as a means of androgen replacement in postmenopausal women, for instance to maintain or increase bone mineral density and decrease the risk of osteoporosis.^{[23][24][25][26]} It is one of only three androgens approved for androgen replacement in postmenopausal women, the others being testosterone (and esters) and methyltestosterone.^[26] Nandrolone esters have more recently been proposed for more widespread treatment of androgen deficiency in men due to favorable properties including their high ratio of anabolic to androgenic effect and hence lower or negligible risk of scalp hair loss, prostate enlargement, and prostate cancer relative to testosterone.^[20][27][28] Nandrolone esters and related compounds such as trestolone and dimethandrolone undecanoate have also been studied as means of androgen replacement in investigational male contraceptive regimens.^[20][29][30]

It has also been proposed for masculinizing hormone therapy in some nonbinary people assigned female at birth who want the body shape effects of testosterone without androgenic hair growth.^[31]

A dosage of nandrolone decanoate of 25 to 50 mg once every 6 to 12 weeks (working out to an average exposure of about 2 to 8 mg per week) by intramuscular injection is considered to be appropriate for general androgen replacement therapy in women.^[32][33][20] A dosage of 50 mg once every 2 to 4 weeks by intramuscular injection is used in the prevention and treatment of postmenopausal osteoporosis and in the palliative treatment of inoperative breast cancer.^[2][6][34] For children aged 2 to 13 years, the average dosage for anemia of chronic kidney disease is 25 to 50 mg every 3 to 4 weeks by intramuscular injection.^[18] Dosages in men and for other uses have also been described.^{[18][19][6][2][3]}

Nandrolone decanoate has been available in 25 mg/mL, 50 mg/mL, 100 mg/mL, and 200 mg/mL formulations in oil solution for intramuscular injection.^[21][3]

Nandrolone decanoate is used for physique- and performance-enhancing purposes by competitive athletes, bodybuilders, and powerlifters.^[3] It is consumed by bodybuilders as per 8–12 weeks bulking cycles with some form of testosterone as a base^[35] because, according to the studies if consumed solo (i.e., without a base) it shuts down the natural production of testosterone by altering blood–testis barrier components.^[36] Despite this fact, nandrolone decanoate is one of the most popular injectable AAS worldwide, and nandrolone esters have been said to be the most popular AAS used by bodybuilders and in sports.^[3][17] This is in part due to the high ratio of anabolic to androgenic effect of nandrolone and its weak propensity for androgenic and estrogenic side effects.^[3][37]

Contraindications for nandrolone decanoate include pregnancy, breastfeeding, prostate cancer, male breast cancer, breast cancer in women with hypercalcemia, hypersensitivity (to nandrolone decanoate or excipients such as arachis (peanut) oil; includes those with peanut and soy allergies), nephrosis or nephritis, liver disease with impaired bilirubin excretion, and heart failure.^[6][18] High dosages may also be considered contraindicated in women due to their high potential for virilization.^[3][6]

The side effects of nandrolone decanoate are dependent on dosage, duration of treatment, and individual sensitivity.^[6][19] A number of common, uncommon, and rare side effects have been observed with the medication at recommended dosages.^[6][19] While less common or severe than with many other AAS, the most common side effect of nandrolone decanoate is virilization (masculinization) in women.^[6][19] Uncommon side effects of nandrolone decanoate at recommended dosages include fluid retention, inhibition of spermatogenesis, testicular atrophy, erectile dysfunction, gynecomastia, increased frequency of penile erections, increased penis size in pre-pubertal boys, clitoral hypertrophy, increased pubic hair growth, oligomenorrhea, amenorrhea, hyperlipidemia, decreased HDL cholesterol, increased hemoglobin (to abnormal high levels), hypertension, nausea, epididymitis, bladder irritability, reduced urine flow, benign prostatic hyperplasia, priapism, premature epiphyseal closure (in children), and acne.^[6] Rare side effects include abnormal liver function, jaundice, peliosis hepatis, liver tumors, oily skin, greasy hair, rash, pruritus, exanthema, urticaria at the injection site, and furunculosis.^[6] Local injection site reactions may also occur.^[19]

Unlike 17α-alkylated AAS such as methyltestosterone, nandrolone decanoate is not associated with liver toxicity.^[3][38]

Nandrolone decanoate causes virilization as a common side effect in women, including acne, hoarseness of the voice, hirsutism (excessive facial/body hair growth), and libido changes, among others.^[6] Clitoral enlargement is an uncommon symptom of virilization that can occur.^[6] Virilization is especially prevalent and marked at high dosages of nandrolone decanoate and/or with long-term treatment, and some aspects of virilization like voice deepening can be irreversible.^[6][19][3] Hoarseness is often the first sign of voice changes.^[6] Although said to be only slightly androgenic, nandrolone decanoate may still occasionally cause virilization at recommended dosages in women, especially with long-term treatment.^[3] A minor though statistically insignificant incidence of virilization has been observed in women treated with nandrolone decanoate short-term at a dosage of 100 mg every 2 weeks for 12 weeks.^[3] Conversely, long-term (>1 year) studies have shown significant virilization in women even at a dosage of 50 mg every 2 or 3 weeks.^[3]

The acute toxicity of nandrolone esters in animals is very low and there are no reports of acute overdosage with nandrolone decanoate in humans.^[2][6] There are no specific recommendations for the management of nandrolone decanoate.^[6]

Antiestrogens like aromatase inhibitors (e.g., anastrozole) and selective estrogen receptor modulators (e.g., tamoxifen, raloxifene) can interfere with and prevent the estrogenic effects of nandrolone decanoate.^[3] 5α-Reductase inhibitors like finasteride and dutasteride can prevent the inactivation of nandrolone in so-called “androgenic” tissues like the skin, hair follicles, and prostate gland, and may therefore considerably increase its androgenic side effects.^[3] This is opposite to the case of most other AAS, which are either potentiated by 5α-reductase in such tissues or are not substrates of 5α-reductase.^[3] Antiandrogens like cyproterone acetate, spironolactone, and bicalutamide can block both the anabolic and androgenic effects of AAS like nandrolone decanoate.^[20]