Buy Dimethyltryptamine (DMT) Cas-61-50-7

Buy Dimethyltryptamine (DMT) Cas-61-50-7

Dimethyltryptamine (DMT), also known as N,N-dimethyltryptamine (N,N-DMT), is a serotonergic hallucinogen and investigational drug of the tryptamine family that occurs naturally in many plants and animals.^[2][3][4][1] DMT is used as a psychedelic drug and prepared by various cultures for ritual purposes as an entheogen.^[11]

DMT has a rapid onset, intense effects, and a relatively short duration of action. For those reasons, DMT was known as the “businessman’s trip” during the 1960s in the United States, as a user could access the full depth of a psychedelic experience in considerably less time than with other substances such as LSD or psilocybin mushrooms.^[12] DMT can be inhaled or injected and its effects depend on the dose, as well as the mode of administration. When inhaled or injected, the effects last about five to fifteen minutes. Effects can last three hours or more when orally ingested along with a monoamine oxidase inhibitor (MAOI), such as the ayahuasca brew of many native Amazonian tribes.^[13] DMT induces intense, often indescribable subjective experiences involving vivid visual hallucinations, altered sensory perception, ego dissolution, and encounters with seemingly autonomous entities. DMT is generally considered non-addictive with low dependence and no tolerance buildup, but it may cause acute psychological distress or cardiovascular effects, especially in predisposed individuals.

DMT was first synthesized in 1931. It is a functional and structural analogue of other psychedelic tryptamines such as 4-AcO-DMT (O-acetylpsilocin),^[14] psilocybin (4-PO-DMT), psilocin (4-HO-DMT), O-methylbufotenin (5-MeO-DMT), and bufotenin (5-HO-DMT). Parts of the structure of DMT occur within some important biomolecules like serotonin and melatonin, making them structural analogues of DMT.

DMT exhibits broad and variable binding affinities across numerous receptors, showing its strongest interactions with serotonin receptors, especially 5-HT_2A, 5-HT_1A, and 5-HT_2C, which are believed to mediate its psychedelic effects. Endogenous DMT, a psychedelic compound, is naturally produced in mammals, with evidence showing its synthesis and presence in brain and body tissues, though its exact roles and origins remain debated. DMT is internationally illegal without authorization, with most countries banning its possession and trade, though some allow religious use of ayahuasca, a DMT-containing decoction. Short-acting psychedelics like DMT are considered scalable alternatives to longer-acting drugs like psilocybin for potential clinical use.^[15][16] DMT is currently undergoing clinical trials for treatment-resistant depression.^[17]

DMT is used either in pure form or in the form of naturally sourced materials.^[2][1] It occurs naturally in many plants, among the more notable species including Psychotria viridis, Mimosa tenuiflora, and Diplopterys cabrerana.^[18][2][19] The drug is often present alongside its close analogues 5-MeO-DMT (mebufotenin) and bufotenin (5-HO-DMT).^[19] It has widely been used as an entheogen or for shamanistic purposes in Central and South America, for instance among Amazonian peoples.^[2] This includes as the traditional beverage ayahuasca and other forms.^[2] Ayahuasca is boiled mixture of different plants, including a DMT-containing plant like Psychotria viridis, Psychotria carthagenensis, or Diplopterys cabrerana together with another plant known as Banisteriopsis caapi.^[2][20] A variety of different recipes may be used to make the brew.^[21] DMT is usually the main active constituent of ayahuasca, but ayahuasca is sometimes also brewed with plants that do not contain DMT.^[22][20] The drug is also found as a minor alkaloid in hallucinogenic snuffs such as those made from Virola or Anadenanthera plant materials but in which the major active drugs are instead 5-MeO-DMT and/or bufotenin.^[19][23] In addition to its use as an entheogen, DMT is widely used recreationally.^[2][3]

DMT is not orally active on its own and is given by parenteral administration, such as smoking, intramuscular injection, subcutaneous injection, or intravenous injection.^{[2][3][1][20]} Other routes like intranasal, buccal, or rectal administration have also been tried but were all reported to be inactive.^[3][1] The lack of oral activity of DMT is due to rapid metabolism by the enzyme monoamine oxidase A (MAO-A).^[2][20] However, when taken in combination with an irreversible monoamine oxidase inhibitor (MAOI) or a reversible inhibitor of MAO-A (RIMA) such as a harmala alkaloid like harmine or harmaline or a pharmaceutical RIMA like moclobemide, DMT becomes orally active with an extended duration relative to parenteral use of DMT alone.^{[2][24][8][20]} Certain plants like Peganum harmala and the Banisteriopsis caapi used in ayahuasca contain harmala alkaloids which allow DMT to become orally active.^[2] When oral DMT is used with an MAOI and the materials are not naturally sourced, the combination is known as pharmahuasca.^[24] Changa is a plant-derived form of DMT that is smoked.^[25] Smoking and intravenous injection of DMT have extremely intense but very-short-lived effects, whereas intramuscular injection and particularly oral administration with an MAOI have less intense but longer-lasting effects.^[3][1]

In his book TiHKAL (Tryptamines I Have Known and Loved) and other publications, Alexander Shulgin lists DMT’s dose as greater than 350 mg orally, 60 to 100 mg by intramuscularly, subcutaneously, or via smoking, and 4 to 30 mg by intravenous injection.^[1][3] He also reported that doses of 150 to 350 mg or even up to 1,000 mg orally and a dose of 100 mg buccally produced no effects, whereas doses of 20 to 80 mg intramuscularly, 30 to 100 mg smoked, and 15 to 30 mg intravenously were all active in producing effects.^{[1][26][18][20]} In terms of intramuscular injection, threshold effects occur at a dose of 30 mg and full effects occur at a dose of 50 to 100 mg by this route.^[26][1] Similarly, the dose for full effects with subcutaneous injection is likewise 60 to 100 mg.^[26] With regard to intravenous injection, a dose of 4 mg was indistinguishable from placebo, 8 mg produced physical effects but no psychoactive effects, 15 mg produced threshold psychedelic effects, and 30 mg produced strong psychedelic effects.^[1] Shulgin lists the duration of parenteral DMT alone as up to 1 hour.^[1]

In other more recent publications, different dose ranges of inhaled DMT of 2 to 100 mg or 15 to 60 mg have been described^[27][28] and typical doses have been reported to be 40 to 50 mg.^[8] Concerning intravenous injection and based on contemporary clinical studies, 15 mg has been described as a low dose, 25 mg as an intermediate or “good effect” dose, and 30 mg as a high or “ego-dissolution” dose.^[29] For intramuscular injection, a range of 50 to 100 mg with an estimated typical dose of 75 mg has been noted.^[30] The onset of DMT has been given as 10 to 15 seconds smoked,^[5][2][4] within 2 to 5 minutes intravenously,^[2] and within 2 to 5 minutes intramuscularly.^[3][4] In addition, its duration is given as 5 to 20 minutes (average 12 minutes) via inhalation,^[3][4][28] less than 30 minutes intravenously,^[4][8] and 30 to 60 minutes intramuscularly.^[3][4]

DMT by continuous intravenous infusion (i.e., an intravenous “drip”, also sometimes known as “DMTx“) has additionally been developed recently and can extend the duration of intravenous DMT to hours.^{[29][31][32][33][34]} The dose range for this route is 0.6 to 1.8 mg per minute, with 0.6 mg/minute being a low dose, 1.2 mg/minute being an intermediate or “good effect” dose, and 1.8 to 2.4 mg/minute being a high or “ego dissolution” dose.^[29][31] In addition to continuous intravenous infusion, DMT vape pens have been developed and distributed as an alternative to smoking.^[35][36][37]