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Mephedrone, also known as 4-methylmethcathinone, 4-MMC, or 4-methylephedrone, is a synthetic stimulant drug belonging to the amphetamine and cathinone classes. It is commonly referred to by slang names such as drone,[5] M-CAT,[6] white magic,[7] meow meow, and bubble.[8] Chemically, it is similar to the cathinone compounds found in the khat plant, native to eastern Africa.[5][9]
Mephedrone is typically found in tablet or crystal form,[10] and users may swallow, snort, or inject it. Its effects are similar to those of MDMA, amphetamines, and cocaine, producing euphoria and increased sociability. Mephedrone is rapidly absorbed, with a half-life of about two hours, and is primarily metabolized by CYP2D6 enzymes. Its effects are dose-dependent. Side effects can include cardiovascular changes[4]: 13 and anxiety.[11][12]
Mephedrone was first synthesised in 1929 but remained relatively obscure until it was rediscovered around 1999–2000. At that time, it was legal to produce and possess in many countries. By 2000, mephedrone was available for sale on the Internet. By 2008, law enforcement agencies had become aware of the substance, and by 2010, it had been reported in most European countries, with significant prevalence in the United Kingdom. Mephedrone was first made illegal in Israel in 2008, followed by Sweden later that year. By 2010, many European countries had banned the substance, and in December of that year, the European Union ruled it illegal. In Australia, New Zealand, and the United States, it is considered an analog of other illegal drugs and can be controlled under laws similar to the US Federal Analog Act. In September 2011, the US temporarily classified mephedrone as a Schedule I drug, with the classification taking effect in October 2011. This was made permanent in July 2012 with the passage of the Synthetic Drug Abuse Prevention Act (SDAPA). Buy 4-MMC (Mephedrone) Cas 1189805-46-6
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Users have reported that mephedrone causes euphoria, stimulation, an enhanced appreciation for music, an elevated mood, decreased hostility, improved mental function and mild sexual stimulation; these effects are similar to the effects of cocaine, amphetamines and MDMA, and last different lengths of time depending on the way the drug is taken. Of 70 Dutch users of mephedrone, 58 described it as an overall pleasant experience and 12 described it as an unpleasant experience.[14] In a survey of UK users who had previously taken cocaine, most users found it produced a better-quality and longer-lasting high and was less addictive. The users were also asked to compare the “risk”, and they answered that it was equal.[15] A study of users in Northern Ireland found they did not equate the fact that mephedrone was legal with it being safe to use. This was contrary to another study in New Zealand, where users of benzylpiperazine thought that because it was legal, it was safe. Buy 4-MMC (Mephedrone) Cas 1189805-46-6, Buy 4-MMC (Mephedrone) Cas 1189805-46-6, Buy 4-MMC (Mephedrone) Cas 1189805-46-6, Buy 4-MMC (Mephedrone) Cas 1189805-46-6, Buy 4-MMC (Mephedrone) Cas 1189805-46-6, Buy 4-MMC (Mephedrone) Cas 1189805-46-6, Buy 4-MMC (Mephedrone) Cas 1189805-46-6, Buy 4-MMC (Mephedrone) Cas 1189805-46-6, Buy 4-MMC (Mephedrone) Cas 1189805-46-6, Buy 4-MMC (Mephedrone) Cas 1189805-46-6, Buy 4-MMC (Mephedrone) Cas 1189805-46-6, Buy 4-MMC (Mephedrone) Cas 1189805-46-6, Buy 4-MMC (Mephedrone) Cas 1189805-46-6, Buy 4-MMC (Mephedrone) Cas 1189805-46-6, Buy 4-MMC (Mephedrone) Cas 1189805-46-6
Available forms
Mephedrone can come in the form of capsules, tablets or white powder that users may swallow, insufflate, inject, smoke or use rectally.[4]: 12 [15][17] When taken orally, users reported they could feel the effects within 15–45 minutes; when snorted, the effects were felt within minutes and peaked within half an hour. The effects last for between two and three hours when taken orally or nasally, but only half an hour if taken intravenously.[4]: 12 It is sometimes sold mixed with methylone in a product called bubbles in the UK[18] and also mixed with other cathinones, including ethcathinone, butylone, fluoromethcathinone and methedrone.[4]: 9
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Purity
One published study that analysed samples of mephedrone bought using the internet in the UK in 2010 found it was racemic (a mixture of both stereoisomers) and of high purity.[19] An unpublished study of six samples also ordered off the internet in the UK in 2010 found they contained very few organic impurities.[20] Four products sold in Irish head shops were tested in 2010 and were found to contain between 82% and 14% mephedrone, with some products containing benzocaine and caffeine.[21]
Adverse effects
Short-term effects
The EMCDDA reported mephedrone can cause various unintended side effects including dilated pupils,[23] poor concentration, teeth grinding, problems focusing visually, poor short-term memory, hallucinations, delusions, and erratic behaviour.[4]: 13 [12] They noted the most severe effects appear anecdotally to be linked with high doses or prolonged use, and the effects may be due to users taking other intoxicants at the same time. Other effects users in internet forums have noted include changes in body temperature, increased heart rate, breathing difficulties, loss of appetite, increased sweating, discolouration of extremities, anxiety, paranoia and depression.[4]: 13 When snorted, it can also cause nose bleeds and nose burns.[4]: 13 [24] A survey conducted by the UK National Addiction Centre found 67% of mephedrone users experienced sweating, 51% suffered from headaches, 43% from heart palpitations, 27% from nausea and 15% from cold or blue fingers,[25] indicative of vasoconstriction occurring.[26] Doctors at Guy’s Hospital in London reported that of 15 patients they treated after taking mephedrone in 2009, 53% were agitated, 40% had increased heart rates, 20% had systolic hypertension and 20% had seizures; three required treatment with benzodiazepines, predominantly to control their agitation. They reported none of their patients suffered from cold or blue peripheries, contrary to other reports. Nine of the 15 of patients had a Glasgow coma scale (GCS) of 15, indicating they were in a normal mental state, four had a GCS below 8, but these patients all reported using a central nervous system depressant, most commonly GHB, with mephedrone. The patients also reported polydrug use of a variety of compounds.[27]
Neurotoxicity
Mephedrone has been found to be a monoaminergic neurotoxin in animals and induces serotonergic neurotoxicity.[28][29][30][31] Although some studies in animal models reported no damage to dopamine nerve endings in the striatum and no significant changes in brain monoamine levels, some others suggested a rapid reduction in serotonin transporter (SERT) and dopamine transporter (DAT) function.[28] Persistent serotonergic deficits were observed after binge like treatment in a warm environment and in both serotonergic and dopaminergic nerve endings at high ambient temperature. Oxidative stress cytotoxicity and an increase in frontal cortex lipid peroxidation were also reported.[30][32] Although mephedrone has been found to be a monoaminergic neurotoxin, in one study, moderate doses of MDMA produced serotonergic neurotoxicity in rodents whereas mephedrone and methylone did not do so, suggesting that cathinones like mephedrone may be less neurotoxic than their corresponding amphetamine counterparts like MDMA.[33][34]
Reinforcement disorders
There have been reports of users craving mephedrone, suggesting it may be addictive.[4]: 13 [14]
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4-MMC (4-Methylmethcathinone, CAS 1189805-46-6) is the archetypal “first-generation” synthetic cathinone that dominated the 2008–2012 legal-high era. Its methyl group at the 4-position of the cathinone backbone gives it a unique balance of monoamine releasing and reuptake inhibition activity.
| Chemical Specifications – 4-MMC Crystal | Details |
|---|---|
| IUPAC Name | (RS)-2-Methylamino-1-(4-methylphenyl)propan-1-one |
| CAS Number | 1189805-46-6 (freebase) / 1189726-22-4 (HCl) |
| Molecular Formula | C₁₁H₁₅NO |
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| Property | Details |
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| CAS Number | 1189805-46-6 |
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Mephedrone
- Chemical Name:Mephedrone
- CAS No.:1189805-46-6
- Molecular Formula:C11H15NO
- Molecular Weight:177.246
- Hs Code.:
- European Community (EC) Number:663-408-3
- UNII:8BA8T27317
- DSSTox Substance ID:DTXSID20891437
- Nikkaji Number:J2.756.280I
- Wikipedia:Mephedrone
- Wikidata:Q262613
- Pharos Ligand ID:R5NGZB4G63PC
- Metabolomics Workbench ID:49630
- ChEMBL ID:CHEMBL4094396
- Mol file:1189805-46-6.mol
Synonyms:4-methylmethcathinone;4-MMC compound;beta-keto-4-methylmethamphetamine;bk-4-methylmethamphetamine;mephedrone;MMCAT compound
This product is a nationally controlled contraband, and the Lookchem platform doesn’t provide relevant sales information.
- Melting Point:232℃
- Boiling Point:280.2 °C at 760 mmHg
- PKA:7.41±0.10(Predicted)
- Flash Point:109.6 °C
- PSA：29.10000
- Density:0.987 g/cm3
- LogP:2.17650
- XLogP3:2
- Hydrogen Bond Donor Count:1
- Hydrogen Bond Acceptor Count:2
- Rotatable Bond Count:3
- Exact Mass:177.115364102
- Heavy Atom Count:13
- Complexity:171
- Purity/Quality:
- Pictogram(s):
- Hazard Codes:
- Canonical SMILES:CC1=CC=C(C=C1)C(=O)C(C)NC
- Recent ClinicalTrials:Mephedrone and Alcohol Interactions in Humans
- DescriptionMephedrone hydrochloride salt is a white powder, whereas its free base is a yellowish liquid at ambient temperature. Mephedrone is typically sold as water-soluble crystalline stable hydrochloride salt powder, white or lightly colored; most probably as a racemic mixture of the R and S enantiomers. The powder can be dissolved for oral/rectal use or for injection. Mephedrone has also been found as capsules containing powder and as tablets pressed from powder.
- UsesMephedrone is used in recreational settings because of its stimulant effects similar to amphetamines (particularlyMDMA) and cocaine. Mephedrone has no established or acknowledged medical value or use (human or veterinary). There are no indications that it may be used for any other purpose.
There total 6 articles about Mephedrone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
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Among the slang terms is a drone, and 4-MMC shares chemical similarities with the cathinone chemicals found in the eastern African khat plant.
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CAS No: 1189805-46-6
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Mol.Wt.: 177.2
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Mol.F.: C11H15NO
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SZ CAT No: SZ-M122004
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