Buy Desmetramadol O-desmethyltramadol (O-DSMT)

Buy Desmetramadol O-desmethyltramadol (O-DSMT)

Desmetramadol (INNTooltip International Nonproprietary Name), also known as O-desmethyltramadol (O-DSMT), is an opioid analgesic and the main active metabolite of tramadol.^[2] Tramadol is demethylated by the liver enzyme CYP2D6^[3] to desmetramadol in the same way as codeine, and so similarly to the variation in effects seen with codeine, individuals who have a less active form of CYP2D6 will tend to have reduced analgesic effects from tramadol. Because desmetramadol itself does not need to be metabolized to induce an analgesic effect, it can be used in individuals with CYP2D6 inactivating mutations.

Desmetramadol is commonly encountered as a designer drug online^[4] in powder form or as an ingredient in pressed pills due to being unscheduled in many jurisdictions. Outside of its role as a metabolite, a chemical used in research, and as a recreational drug, desmetramadol has a very limited history of human usage and is not approved for medicinal use in any country as of 2025.

(+)-Desmetramadol is a G-protein biased μ-opioid receptor full agonist.^[5] It shows comparatively far lower affinity for the δ- and κ-opioid receptors.^[6] The two enantiomers of desmetramadol show quite distinct pharmacological profiles;^[7] both (+) and (−)-desmetramadol are inactive as serotonin reuptake inhibitors,^[8] but (−)-desmetramadol retains activity as a norepinephrine reuptake inhibitor,^[9] and so the mix of both the parent compound and metabolites contributes significantly to the complex pharmacological profile of tramadol. While the multiple receptor targets can be beneficial in the treatment of pain (especially complex pain syndromes such as neuropathic pain), they increase the potential for drug interactions compared to other opioids, and may also contribute to side effects. Desmetramadol is also an antagonist of the serotonin 5-HT_2C receptor, at pharmacologically relevant concentrations, via competitive inhibition.^[10] This suggests that the apparent anti-depressant properties of tramadol may be at least partially mediated by desmetramadol, thus prolonging the duration of therapeutic benefit. Inhibition of the 5-HT_2C receptor is a suggested factor in the mechanism of anti-depressant effects of agomelatine and maprotiline. The potential selectivity and favorable side effect profile of desmetramadol compared to tramadol, makes it more suitable for use as antidepressant, although clinical development appears to have stopped. Upon inhibition of the receptor, downstream signaling causes dopamine and norepinephrine release, and the receptor is thought to significantly regulate mood, anxiety, feeding, and reproductive behavior. 5-HT_2C receptors regulate dopamine release in the striatum, prefrontal cortex, nucleus accumbens, hippocampus, hypothalamus, and amygdala, among others.^[11] Research indicates that some suicide victims have an abnormally high number of 5-HT_2C receptors in the prefrontal cortex.^[12] There is some mixed evidence that agomelatine, a 5-HT_2C antagonist, is an effective antidepressant.^[13] Antagonism of 5-HT_2C receptors by agomelatine results in an increase of dopamine and norepinephrine activity in the frontal cortex.

Buy O-DSMT online

O-Desmethyltramadol (O-DSMT) is an opioid that has primarily been used indirectly due to it being a primary metabolite of the analgesic tramadol. It has other names such as O-Desmethyltramadol, Desmetramadol, O-DSMT, Omnitram, has a strong similarity in action on Furanyl-Fentanyl. is a synthetic opipodic drug, an active metabolite of tramadol of the cyclohexanol class. O-DSMT IUPAC: 3- (2 – ((dimethylamino) methyl) -1-hydroxycyclohexyl) phenol. o-dsmt has a similar molecular structure to tramadol.Firstly O-DSMT has good analgesic properties, acts as a sedative, euphoric, but can quickly become addictive. It has the most potent effect compared to tramadol. Buy O-DSMT online

Desmetramadol is metabolized in the liver into the active metabolite N,O-didesmethyltramadol via CYP3A4 and CYP2B6. The inactive tramadol metabolite N-desmethyltramadol is metabolized into the active metabolite N,O-didesmethyltramadol by CYP2D6

 

Do you want to buy O-DSMT Powder, O-desmethyltramadol or Desmetramadol? Then you have come to the right place! All research chemicals on our web-shop are laboratory tested and of the purest quality. Orders are packaged discreetly and shipped within 24 hours. In addition, you can pay safely and quickly via Bitcoin and crypto.

Where can I buy O-DSMT?

At our web-shop you can find all your research chemicals and here you can also order the best quality O-DSMT.

This substance is intended for laboratory use only.

Always make sure you take adequate safety precautions. For example, remember to cover exposed skin and wear safety glasses.

Please note: Like other research chemicals, O-DSMT is only intended for research purposes and should absolutely not be consumed by humans, animals or other living organisms.

Store in a dry, cool place for maximum shelf life.

We do not sell research chemicals to persons under the age of 18

Buy ODSMT Online – Premium Research Chemical | Chems Connect

Welcome to Chems Connect, your trusted source for premium O-DSMT, a popular research chemical known for its unique properties. Explore the benefits of O-DSMT and its potential applications in research and scientific studies.

Discover O-DSMT:
O-DSMT, also known as O-Desmethyltramadol, is a synthetic opioid compound derived from tramadol. It exhibits analgesic properties and is often used in laboratory settings for research purposes. O-DSMT interacts with opioid receptors in the central nervous system, producing effects similar to other opioids.

Key Features and Characteristics of odsmt

• Pain Relief: This product is a potent analgesic that can provide relief from moderate to severe pain. It exerts its analgesic effects by binding to the mu-opioid receptors in the central nervous system, thereby reducing the perception of pain.
• Opioid Activity:  This product exhibits opioid-like activity due to its structural similarity to tramadol. It acts as a mu-opioid receptor agonist, which results in pain relief, sedation, and euphoria.
• Metabolism:  This product is a metabolite of tramadol. Tramadol is metabolized in the liver by the enzyme CYP2D6 to form O-DSMT. This metabolite has a longer half-life than tramadol, leading to prolonged effects.
• Research Chemical: This product is frequently used as a research chemical. Researchers study its pharmacological properties, potential therapeutic applications, and its effects on opioid receptors and pain pathways.
• Dosage: The suggested dosage of this product is 1mg. However, it is crucial to note that dosages should be determined by researchers based on their specific experimental requirements and in compliance with legal and ethical guidelines.
• Storage:  This product should be stored in a cool, dry place, away from direct sunlight, moisture, and heat. The substance should be securely stored to prevent unauthorized access. Ordering Information:
  To inquire about pricing, and availability, or to place an order for O-DSMT 1mg Pellets or any other research chemicals, please visit our website or contact our customer support team. Our dedicated team is available to assist you with any questions or concerns you may have.

Explore the Effects and Dosage Guidelines of ODSMT

Premium Quality and Purity:
At Chems Connect, we prioritize quality and purity. This product is sourced from reputable manufacturers and undergoes rigorous testing to ensure it meets the highest industry standards. We are committed to providing researchers with reliable and premium-grade products for their scientific investigations.

Convenient Online Purchase:
With Chems Connect, buying O-DSMT is easy and convenient. Our user-friendly online platform allows you to browse our selection, place an order, and have it delivered right to your doorstep. We prioritize discreet packaging to ensure the privacy of our customers.

Safety and Compliance:
We prioritize safety and compliance with all applicable regulations. It is essential to handle this product with caution and adhere to appropriate safety protocols when conducting research. Chems Connect encourages responsible use and strict adherence to legal regulations regarding research chemicals.

Dosage and Usage Guidelines:
Accurate dosage and proper usage are crucial when working with research chemicals like O-DSMT. Researchers should consult relevant scientific literature and follow established protocols to ensure safe and effective use. Our team at Chems Connect is available to address any inquiries and provide guidance regarding dosage and usage.

Order Today:
Start your research journey by ordering O-DSMT from Chems Connect. Explore the potential applications of this synthetic opioid compound in your scientific studies and gain valuable insights. Trust us to provide you with top-quality research chemicals and excellent customer service.

Chems Connect – Connecting you with the research chemicals you need for cutting-edge scientific research.

1. O-Desmethyltramadol (O-DSMT) 50 Grams – O-DSMT

   The ODSMT is manufactured under ISO/IEC 17025:2005 and ISO Guide 34:2009 specifications. O-DSMT is an opioid analgesic and the main active metabolite of tramadol.
2. O-DSMT – TeamChemists.com supplier of research …

   5 days ago · You can buy O-DSMT online at teamchemists.com. O-Desmethyltramadol or O-DSMT is an opioid drug of the phenylpropylamine …
3. O-DSMT – OmniCompound is a supplier of new …

   You can get acquainted with the prices and buy O-DSMT online right now, at OmniCompound company. We provide all the necessary information about the …

   • 4.8/5

     (11)
   • Molecular Formula: C15H23NO2

   • CAS: 80456-81-1
   • Molecular Weight: 249.354 g·mol−1
4. Buy ODSMT Online – Premium Quality Research Chemical – Chems …

   Sep 27, 2023 · Purchase ODSMT online from Chems Connect, your trusted source for high-quality research chemicals. Explore the benefits of O-DSMT and order securely for fast delivery. Find …
5. O-Desmethyltramadol 10grams – ODSMT

   For research use only. Each order may only buy 1 unit. Purity: 99.9% min. This O-Desmethyltramadol has been manufactured and tested to meet ISO17025:2005 and Guide 34:2009 guidelines.

6. O-DSMT – Research Chemicals online

   Buy O-DSMT online. O-Desmethyltramadol (O-DSMT) is an opioid that has primarily been used indirectly due to it being a primary metabolite of the analgesic tramadol.
7. O-DSMT – Chemical Route

   O-DSMT is a high-affinity ligand that can be used to treat opioid dependence. It’s similar to the – and -opioid receptors. Both O-DSMT and its metabolites are active reuptake inhibitors.
8. O-DSMT Supplier Europe – Buy Opioids, Research …

   Do you want to buy O-DSMT Powder, O-desmethyltramadol or Desmetramadol? Then you have come to the right place! All research chemicals on our web-shop are laboratory tested and of the purest quality. Orders are packaged discreetly …

9. Buy O-DSMT Powder – 3-MMC? – koop3mmc.nl

   O-Desmethyltramadol, also known as O-DSMT and desmetramadol, belongs to the opioid substances of the cyclohexanol class. It is an active metabolite of tramadol, intended …

   • Reviews: 15
10. 

    O-DMST, O-Desmethyltramadol – 

    Why buy O-DSMT online from biochemal.com? • You buy a quality product at the best price, without intermediary markups. • You are buying a tested product that has proven itself in the designer drugs market.